The crystal structure of catechol oxidase: New insight into the function of type-3 copper proteins

被引：506

作者：

Gerdemann, C

Eicken, C

Krebs, B

机构：

[1] Univ Munster, Inst Anorgan & Analyt Chem, D-48149 Munster, Germany

[2] Univ Munster, Inst Biochem, D-48149 Munster, Germany

来源：

ACCOUNTS OF CHEMICAL RESEARCH | 2002年 / 35卷 / 03期

关键词：

D O I：

10.1021/ar990019a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The crystal structure of catechol oxidase reveals new insight into the functional properties of the type-3 copper proteins. This class of proteins includes the closely related and better-known tyrosinase as well as hemocyanin, an oxygen transport protein. All these proteins have a dinuclear copper center, have similar spectroscopic behaviors, and show close evolutionary and functional relationships. Comparison between the 3D structures of catechol oxidase and hemocyanins reveals the structural reasons for the divergence in function.

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页码：183 / 191

页数：9

相关论文

共 41 条

[1]

ADMAN ET, 1991, ADV PROTEIN CHEM, V42, P145

[2]

AKRLIN KD, 1997, ACCOUNTS CHEM RES, P139

[3] Review:: Enzymatic browning in minimally processed fruit and vegetables [J].

Artés, F ;

Castañer, M ;

Gil, MI .

FOOD SCIENCE AND TECHNOLOGY INTERNATIONAL, 1998, 4 (06) :377-389

[4] 1H NMR spectroscopy of the binuclear Cu(II) active site of Streptomyces antibioticus tyrosinase [J].

Bubacco, L ;

Salgado, J ;

Tepper, AWJW ;

Vijgenboom, E ;

Canters, GW .

FEBS LETTERS, 1999, 442 (2-3) :215-220

[5] Crystal structure of a functional unit from Octopus hemocyanin [J].

Cuff, ME ;

Miller, KI ;

van Holde, KE ;

Hendrickson, WA .

JOURNAL OF MOLECULAR BIOLOGY, 1998, 278 (04) :855-870

[6] Tyrosinase/catecholoxidase activity of hemocyanins: structural basis and molecular mechanism [J].

Decker, H ;

Tuczek, F .

TRENDS IN BIOCHEMICAL SCIENCES, 2000, 25 (08) :392-397

[7] Biochemical and spectroscopic characterization of catechol oxidase from sweet potatoes (Ipomoea batatas) containing a type-3 dicopper center [J].

Eicken, C ;

Zippel, F ;

Büldt-Karentzopoulos, K ;

Krebs, B .

FEBS LETTERS, 1998, 436 (02) :293-299

[8] Catechol oxidase - structure and activity [J].

Eicken, C ;

Krebs, B ;

Sacchettini, JC .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1999, 9 (06) :677-683

[9] 4-hydroxyanisole:: The most suitable monophenolic substrate for determining spectrophotometrically the monophenolase activity of polyphenol oxidase from fruits and vegetables [J].

Espín, JC ;

Tudela, J ;

García-Cánovas, F .

ANALYTICAL BIOCHEMISTRY, 1998, 259 (01) :118-126

[10] 3.2 A STRUCTURE OF THE COPPER-CONTAINING, OXYGEN-CARRYING PROTEIN PANULIRUS-INTERRUPTUS HEMOCYANIN [J].

GAYKEMA, WPJ ;

HOL, WGJ ;

VEREIJKEN, JM ;

SOETER, NM ;

BAK, HJ ;

BEINTEMA, JJ .

NATURE, 1984, 309 (5963) :23-29

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