Study Objective. To compare total laparoscopic hysterectomy (TLH) with open hysterectomy in the management of endometrial carcinoma. Design. Retrospective chart review (Canadian Task Force classification 11-3). Setting. Gynecologic cancer center. Patients. All women with endometrial carcinoma managed between January 1, 1993, and June 30, 1999. Interventions. Of 403 patients reviewed, in 167 (40%) the surgical intention was laparoscopic management, in 230 (57%) the intention was open management, and in 12 (3%) it was vaginal hysterectomy Total laparoscopic hysterectomy was successfully completed in 153 (95%) of the laparoscopic group. Measurements and Main Results. Mean weight of women in the laparoscopic group (80.7 kg) was greater than that in the open group (73.3 kg, p = 0.002), and included 27 patients weighing over 100 kg (maximum individual weight 170 kg), Mean operating times were 138 minutes for laparoscopy and 12 7 minutes for the open procedure (p = 0.002). Complications differed, with significantly more occurring in the open group (43%, 100) than in the laparoscopic group (17%, 27, p <0.00001). Mean postoperative hospital stay was significantly shorter for the laparoscopic group (4.3 days) than for the open group (8.5 days, p = 0.0001). Conclusion. TLH combined with laparoscopic surgical stiging has many advantages over the open approach, especially in obese women.