N-aryl cinnamides: A novel class of rigid and highly potent leukotriene B-4 receptor antagonists

被引：6

作者：

Greenspan, PD

Main, AJ

Bhagwat, SS

Barsky, LI

Doti, RA

Engle, AR

Frey, LM

Zhou, HH

Lipson, KE

Chin, MH

Jackson, RH

UzielFusi, S

机构：

[1] Arthr. and Bone Metabolism Research, Novartis Pharmaceuticals Corporation, Summit

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(97)00134-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of N-aryl cinnamides has been prepared and assayed for antagonism of the leukotriene B-4 receptor. Several compounds in this series were found to be highly potent antagonists of the human neutrophil receptor, based on a whole cell binding assay, as well as a neutrophil aggregration assay. This series is unique among LTB4 antagonists, due to its high degree of rigidity. (C) 1997 Elsevier Science Ltd.

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页码：949 / 954

页数：6

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