TLR4 polymorphisms and disease susceptibility

被引：138

作者：

Noreen, Mamoona ^{[1
]}

Shah, Muhammad Ali A. ^{[1
]}

Mall, Sheeba Murad ^{[1
]}

Choudhary, Shazia ^{[1
]}

Hussain, Tahir ^{[1
]}

Ahmed, Iltaf ^{[1
]}

Jalil, Syed Fazal ^{[1
]}

Raza, Muhammad Imran ^{[1
]}

机构：

[1] NUST, NCVI, Islamabad, Pakistan

来源：

INFLAMMATION RESEARCH | 2012年 / 61卷 / 03期

关键词：

Immunity; Infection; TLR4; Polymorphism; Susceptibility; Disease; TOLL-LIKE RECEPTOR-4; NF-KAPPA-B; RESPIRATORY SYNCYTIAL VIRUS; BRUTONS TYROSINE KINASE; PROSTATE-CANCER RISK; LIPOPOLYSACCHARIDE-BINDING PROTEIN; SINGLE-NUCLEOTIDE POLYMORPHISMS; ASP299GLY POLYMORPHISM; GASTRIC-CANCER; TOLL-LIKE-RECEPTOR-4; POLYMORPHISMS;

D O I：

10.1007/s00011-011-0427-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Toll-like receptors (TLRs) play a central role in the regulation of the host immune system. Each TLR recognizes specific pathogen-associated molecular patterns (PAMPs). TLR4 is one of the well characterized pathogen recognition receptors (PRRs) that recognizes the lipopolysaccharide (LPS) of Gram-negative bacteria, some conserved structures from fungal to mycobacterial pathogens and some endogenous ligands. A complex signaling cascade initiates after the ligand binds to the TLR4 ectodomain, leading to the activation of multiple inflammatory genes. Genetic variations greatly influence immune responses towards pathogenic challenges and disease outcome. In this review, we summarize various reports regarding TLR4 polymorphisms and disease susceptibility.

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收藏

页码：177 / 188

页数：12

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