A new cytotoxic prenylated dihydrobenzofuran derivative and other chemical constituents from the rhizomes of Atractylodes lancea DC

被引：107

作者：

Duan, Jin-ao ^{[1
]}

Wang, Liuying ^{[2
,3
]}

Qian, Shihui ^{[4
]}

Su, Shulan ^{[1
,2
]}

Tang, Yuping ^{[1
]}

机构：

[1] Nanjing Univ Chinese Med, Jiangsu Key Lab TCM Formulae Res, Nanjing 210046, Peoples R China

[2] Jiangsu Univ, Pharmaceut Coll, Zhenjiang 212013, Peoples R China

[3] Nanjing Hailing R&D Chinese Tradit Med, Nanjing 210049, Peoples R China

[4] Jiangsu Inst Tradit Chinese Med, Nanjing 210028, Peoples R China

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2008年 / 31卷 / 08期

关键词：

Atractylodes lancea; asteraceae; constituent; atractylenolide; dihydrobenzofuran; cytotoxicity;

D O I：

10.1007/s12272-001-1252-z

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

A new prenylated dihydrobenzofuran derivative (1), was isolated from the rhizomes of Atractylodes lancea DC (Asteraccae), along with ten known Compounds, including atractylencilide II (2), phi-taraxasteryl acetate (3), taraxerol acetate (4). beta-sitosterol (5), stigmasterol (6), beta-eudesmol (7), atractylenolide III (8), atractylenolide IV (9), daucosterol (10), and stigmasterol 3-O-beta-D-glucopyranoside (11). The structure of the new compound (1) was elucidated as trans-2-hydroxyisoxypropyl-3-hydroxy-7-isopentene-2,3-dihydrobenzofuran-5-carboxylic acid by the combination of 1D, 2D NMR analysis and mass spectrometry, and it was the first reported 2,3-dihydrobenzofuran derivative having a carboxyl residue at C-5 and ail isopentene moiety at C-7 contemporaneously. In addition, compound 1 exhibited significant cytotoxicity against cancer cell lines HCT-116 and MKN-45.

引用

页码：965 / 969

页数：5

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