Three types of sesquiterpenes from rhizomes of Atractylodes lancea

被引：131

作者：

Wang, He-Xiang ^{[1
]}

Liu, Chun-Mei ^{[1
]}

Liu, Quan ^{[1
]}

Gao, Kun ^{[1
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

PHYTOCHEMISTRY | 2008年 / 69卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Atractylodes lancea; Compositae; sesquiterpene; guaiane; eudesmane; cytotoxicity;

D O I：

10.1016/j.phytochem.2008.04.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Eight sesquiterpenes, including four guaiane-types containing an interesting epoxy unit (1-4), a rare tricyclic carbon skeleton-type (5) and three eudesmane-types (6-8), along with five known compounds, were isolated from rhizomes of Atractylodes lancea. The structures and relative configurations of 1-8 were determined by analysis of spectroscopic data, and the absolute configuration of 8 was assigned by application of the CD technique. Compounds 1, 2 and 4 were evaluated for their cytotoxic effects against P388 and A549 cells, but all were inactive. Possible biosynthetic pathways for sesquiterpenes (1-8) were discussed. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2088 / 2094

页数：7

共 32 条

[1]

Bebryazulene, a new guaiane metabolite from the Indian Ocean gorgonian coral, Bebryce grandicalyx [J].