Tyrosine kinome sequencing of pediatric acute lymphoblastic leukemia: a report from the Children's Oncology Group TARGET Project

被引：138

作者：

Loh, Mignon L. ^{[1
,2
]}

Zhang, Jinghui ^{[3
]}

Harvey, Richard C. ^{[4
]}

Roberts, Kathryn ^{[5
]}

Payne-Turner, Debbie ^{[5
]}

Kang, Huining ^{[4
]}

Wu, Gang ^{[3
,6
]}

Chen, Xiang ^{[3
,6
]}

Becksfort, Jared ^{[3
,6
]}

Edmonson, Michael ^{[7
]}

Buetow, Kenneth H. ^{[7
]}

Carroll, William L. ^{[8
]}

Chen, I-Ming ^{[4
]}

Wood, Brent ^{[9
]}

Borowitz, Michael J. ^{[10
]}

Devidas, Meenakshi ^{[11
]}

Gerhard, Daniela S. ^{[12
]}

Bowman, Paul ^{[13
]}

Larsen, Eric ^{[14
]}

Winick, Naomi ^{[15
]}

Raetz, Elizabeth ^{[8
]}

Smith, Malcolm ^{[16
]}

Downing, James R. ^{[5
]}

Willman, Cheryl L. ^{[4
]}

Mullighan, Charles G. ^{[5
]}

Hunger, Stephen P. ^{[17
,18
]}

机构：

[1] Univ Calif San Francisco, Dept Pediat, San Francisco, CA USA

[2] Univ Calif San Francisco, Helen Diller Family Canc Ctr, San Francisco, CA USA

[3] St Jude Childrens Res Hosp, Dept Computat Biol & Bioinformat, Memphis, TN 38105 USA

[4] Univ New Mexico, Canc Res & Treatment Ctr, Albuquerque, NM 87131 USA

[5] St Jude Childrens Res Hosp, Dept Pathol, Memphis, TN 38105 USA

[6] St Jude Childrens Res Hosp, Dept Informat Sci, Memphis, TN 38105 USA

[7] NIH, Lab Populat Genet, Bethesda, MD 20892 USA

[8] NYU, Inst Canc, New York, NY USA

[9] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[10] Johns Hopkins Univ, Dept Pathol, Baltimore, MD USA

[11] Univ Florida, Coll Med, Gainesville, FL USA

[12] NIH, Off Canc Genom, Bethesda, MD 20892 USA

[13] Univ N Texas, Cook Childrens Med Ctr, Hlth Sci Ctr, Ft Worth, TX USA

[14] Maine Childrens Canc Program, Scarborough, ME USA

[15] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA

[16] NCI, Canc Therapy Evaluat Program, NIH, Bethesda, MD 20892 USA

[17] Univ Colorado, Sch Med, Aurora, CO USA

[18] Childrens Hosp Colorado, Ctr Canc & Blood Disorders, Aurora, CO 80045 USA

来源：

BLOOD | 2013年 / 121卷 / 03期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

MINIMAL RESIDUAL DISEASE; B-PROGENITOR; EXPRESSION; CRLF2; CLASSIFICATION; REARRANGEMENT; MUTATIONS; SURVIVAL; DELETION; RELAPSE;

D O I：

10.1182/blood-2012-04-422691

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

One recently identified subtype of pediatric B-precursor acute lymphoblastic leukemia (ALL) has been termed BCR-ABL1-like or Ph-like because of similarity of the gene expression profile to BCR-ABL1 positive ALL suggesting the presence of lesions activating tyrosine kinases, frequent alteration of IKZF1, and poor outcome. Prior studies demonstrated that approximately half of these patients had genomic lesions leading to CRLF2 overexpression, with half of such cases harboring somatic mutations in the Janus kinases JAK1 and JAK2. To determine whether mutations in other tyrosine kinases might also occur in ALL, we sequenced the tyrosine kinome and downstream signaling genes in 45 high-risk pediatric ALL cases with either a Ph-like gene expression profile or other alterations suggestive of activated kinase signaling. Aside from JAK mutations and 1 FLT3 mutation, no somatic mutations were found in any other tyrosine kinases, suggesting that alternative mechanisms are responsible for activated kinase signaling in high-risk ALL. (Blood. 2013;121(3):485-488)

引用

页码：485 / 488

页数：4

共 20 条

[1]

Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome [J].

Bercovich, Dani ;

Ganmore, Ithamar ;

Scott, Linda M. ;

Wainreb, Gilad ;

Birger, Yehudit ;

Elimelech, Arava ;

Chen, Shochat ;

Cazzaniga, Giovanni ;

Biondi, Andrea ;

Basso, Giuseppe ;

Cario, Gunnar ;

Schrappe, Martin ;

Stanulla, Martin ;

Strehl, Sabine ;

Haas, Oskar A. ;

Mann, Georg ;

Binder, Vera ;

Borkhardt, Arndt ;

Kempski, Helena ;

Trka, Jan ;

Bielorei, Bella ;

Avigad, Smadar ;

Stark, Batia ;

Smith, Owen ;

Dastugue, Nicole ;

Bourquin, Jean-Pierre ;

Ben Tal, Nir ;

Green, Anthony R. ;

Izraeli, Shai .

LANCET, 2008, 372 (9648) :1484-1492

[2]

Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic factors: a Children's Oncology Group study [J].

Borowitz, Michael J. ;

Devidas, Meenakshi ;

Hunger, Stephen P. ;

Bowman, W. Paul ;

Carroll, Andrew J. ;

Carroll, William L. ;

Linda, Stephen ;

Martin, Paul L. ;

Pullen, D. Jeanette ;

Viswanatha, David ;

Willman, Cheryl L. ;

Winick, Naomi ;

Camitta, Bruce M. .

BLOOD, 2008, 111 (12) :5477-5485

[3]

Augmented Therapy Improves Outcome for Pediatric High Risk Acute Lymphocytic Leukemia: Results Of Children's Oncology Group Trial P9906 [J].

Bowman, W. Paul ;

Larsen, Eric L. ;

Devidas, Meenakshi ;

Linda, Stephen B. ;

Blach, Laurie ;

Carroll, Andrew J. ;

Carroll, William L. ;

Pullen, D. Jeanette ;

Shuster, Jonathan ;

Willman, Cheryl L. ;

Winick, Naomi ;

Camitta, Bruce M. ;

Hunger, Stephen P. ;

Borowitz, Michael J. .

PEDIATRIC BLOOD & CANCER, 2011, 57 (04) :569-577

[4]

A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study [J].

Den Boer, Monique L. ;

van Slegtenhorst, Marjon ;

De Menezes, Renee X. ;

Cheok, Meyling H. ;

Buijs-Gladdines, Jessica G. C. A. M. ;

Peters, Susan T. C. J. M. ;

Van Zutven, Laura C. M. ;

Beverloo, H. Berna ;

Van der Spek, Peter J. ;

Escherich, Gaby ;

Horstmann, Martin A. ;

Janka-Schoub, Gritta E. ;

Kamps, Willem A. ;

Evans, William E. ;

Pieters, Rob .

LANCET ONCOLOGY, 2009, 10 (02) :125-134

[5]

Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome [J].

Harvey, Richard C. ;

Mullighan, Charles G. ;

Wang, Xuefei ;

Dobbin, Kevin K. ;

Davidson, George S. ;

Bedrick, Edward J. ;

Chen, I-Ming ;

Atlas, Susan R. ;

Kang, Huining ;

Ar, Kerem ;

Wilson, Carla S. ;

Wharton, Walker ;

Murphy, Maurice ;

Devidas, Meenakshi ;

Carroll, Andrew J. ;

Borowitz, Michael J. ;

Bowman, W. Paul ;

Downing, James R. ;

Relling, Mary ;

Yang, Jun ;

Bhojwani, Deepa ;

Carroll, William L. ;

Camitta, Bruce ;

Reaman, Gregory H. ;

Smith, Malcolm ;

Hunger, Stephen P. ;

Willman, Cheryl L. .

BLOOD, 2010, 116 (23) :4874-4884

[6]

Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia [J].

Harvey, Richard C. ;

Mullighan, Charles G. ;

Chen, I-Ming ;

Wharton, Walker ;

Mikhail, Fady M. ;

Carroll, Andrew J. ;

Kang, Huining ;

Liu, Wei ;

Dobbin, Kevin K. ;

Smith, Malcolm A. ;

Carroll, William L. ;

Devidas, Meenakshi ;

Bowman, W. Paul ;

Camitta, Bruce M. ;

Reaman, Gregory H. ;

Hunger, Stephen P. ;

Downing, James R. ;

Willman, Cheryl L. .

BLOOD, 2010, 115 (26) :5312-5321

[7]

Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group [J].

Hertzberg, Libi ;

Vendramini, Elena ;

Ganmore, Ithamar ;

Cazzaniga, Gianni ;

Schmitz, Maike ;

Chalker, Jane ;

Shiloh, Ruth ;

Iacobucci, Ilaria ;

Shochat, Chen ;

Zeligson, Sharon ;

Cario, Gunnar ;

Stanulla, Martin ;

Strehl, Sabine ;

Russell, Lisa J. ;

Harrison, Christine J. ;

Bornhauser, Beat ;

Yoda, Akinori ;

Rechavi, Gideon ;

Bercovich, Dani ;

Borkhardt, Arndt ;

Kempski, Helena ;

Kronnie, Geertruy Te ;

Bourquin, Jean-Pierre ;

Domany, Eytan ;

Izraeli, Shai .

BLOOD, 2010, 115 (05) :1006-1017

[8]

Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia [J].

Kang, Huining ;

Chen, I. -Ming ;

Wilson, Carla S. ;

Bedrick, Edward J. ;

Harvey, Richard C. ;

Atlas, Susan R. ;

Devidas, Meenakshi ;

Mullighan, Charles G. ;

Wang, Xuefei ;

Murphy, Maurice ;

Ar, Kerem ;

Wharton, Walker ;

Borowitz, Michael J. ;

Bowman, W. Paul ;

Bhojwani, Deepa ;

Carroll, William L. ;

Camitta, Bruce M. ;

Reaman, Gregory H. ;

Smith, Malcolm A. ;

Downing, James R. ;

Hunger, Stephen P. ;

Willman, Cheryl L. .

BLOOD, 2010, 115 (07) :1394-1405

[9]

BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros [J].

Mullighan, Charles G. ;

Miller, Christopher B. ;

Radtke, Ina ;

Phillips, Letha A. ;

Dalton, James ;

Ma, Jing ;

White, Deborah ;

Hughes, Timothy P. ;

Le Beau, Michelle M. ;

Pui, Ching-Hon ;

Relling, Mary V. ;

Shurtleff, Sheila A. ;

Downing, James R. .

NATURE, 2008, 453 (7191) :110-+

[10]

Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia [J].

Mullighan, Charles G. ;

Collins-Underwood, J. Racquel ;

Phillips, Letha A. A. ;

Loudin, Michael G. ;

Liu, Wei ;

Zhang, Jinghui ;

Ma, Jing ;

Coustan-Smith, Elaine ;

Harvey, Richard C. ;

Willman, Cheryl L. ;

Mikhail, Fady M. ;

Meyer, Julia ;

Carroll, Andrew J. ;

Williams, Richard T. ;

Cheng, Jinjun ;

Heerema, Nyla A. ;

Basso, Giuseppe ;

Pession, Andrea ;

Pui, Ching-Hon ;

Raimondi, Susana C. ;

Hunger, Stephen P. ;

Downing, James R. ;

Carroll, William L. ;

Rabin, Karen R. .

NATURE GENETICS, 2009, 41 (11) :1243-U111

← 1 2 →