The Pathogenesis of the Antiphospholipid Syndrome

被引：461

作者：

Giannakopoulos, Bill ^{[1
,2
,3
]}

Krilis, Steven A. ^{[1
,3
]}

机构：

[1] Univ New S Wales, St George Hosp, Dept Infect Dis Immunol & Sexual Hlth, Sydney, NSW 2217, Australia

[2] Univ New S Wales, St George Hosp, Dept Rheumatol, Sydney, NSW 2217, Australia

[3] Univ New S Wales, St George Clin Sch, Dept Med, Sydney, NSW 2217, Australia

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2013年 / 368卷 / 11期

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; ENDOTHELIAL-CELL ACTIVATION; NITRIC-OXIDE SYNTHASE; IN-VIVO; TISSUE FACTOR; FACTOR-XI; BETA(2)-GLYCOPROTEIN I; DOMAIN-I; ANTI-BETA(2)-GLYCOPROTEIN-I ANTIBODIES; VENOUS THROMBOSIS;

D O I：

10.1056/NEJMra1112830

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

[No abstract available]

引用

页码：1033 / 1044

页数：12

共 108 条

[1] β2-Glycoprotein I can exist in 2 conformations: implications for our understanding of the antiphospholipid syndrome [J].

Agar, Cetin ;

van Os, Gwendolyn M. A. ;

Morgelin, Matthias ;

Sprenger, Richard R. ;

Marquart, J. Arnoud ;

Urbanus, Rolf T. ;

Derksen, Ronald H. W. M. ;

Meijers, Joost C. M. ;

de Groot, Philip G. .

BLOOD, 2010, 116 (08) :1336-1343

[2] In vivo distribution of β2 glycoprotein I under various pathophysiologic conditions [J].

Agostinis, Chiara ;

Biffi, Stefania ;

Garrovo, Chiara ;

Durigutto, Paolo ;

Lorenzon, Andrea ;

Bek, Alpan ;

Bulla, Roberta ;

Grossi, Claudia ;

Borghi, Maria O. ;

Meroni, PierLuigi ;

Tedesco, Francesco .

BLOOD, 2011, 118 (15) :4231-4238

[3] A novel pathway for human endothelial cell activation by antiphospholipid/anti-β2 glycoprotein I antibodies [J].

Allen, Kristi L. ;

Fonseca, Fabio V. ;

Betapudi, Venkaiah ;

Willard, Belinda ;

Zhang, Jainwei ;

McCrae, Keith R. .

BLOOD, 2012, 119 (03) :884-893

[4] Antibodies to high-density lipoprotein and β2-glycoprotein I are inversely correlated with paraoxonase activity in systemic lupus erythematosus and primary antiphospholipid syndrome [J].

Alves, JD ;

Ames, PRJ ;

Donohue, S ;

Stanyer, L ;

Noorouz-Zadeh, J ;

Ravirajan, C ;

Isenberg, DA .

ARTHRITIS AND RHEUMATISM, 2002, 46 (10) :2686-2694

[5] Clinical Relevance of Nitric Oxide Metabolites and Nitrative Stress in Thrombotic Primary Antiphospholipid Syndrome [J].

Ames, Paul R. J. ;

Batuca, Joana R. ;

Ciampa, Antonio ;

Iannaccone, Luigi ;

Alves, Jose Delgado .

JOURNAL OF RHEUMATOLOGY, 2010, 37 (12) :2523-2530

[6]

Ames PRJ, 1998, THROMB HAEMOSTASIS, V79, P447

[7] β2-glycoprotein-1 autoantibodies from patients with antiphospholipid syndrome are sufficient to potentiate arterial thrombus formation in a mouse model [J].

Arad, Ariela ;

Proulle, Valerie ;

Furie, Richard A. ;

Furie, Barbara C. ;

Furie, Bruce .

BLOOD, 2011, 117 (12) :3453-3459

[8] Autoreactive CD4+ T-cell clones to β2-glycoprotein I in patients with antiphospholipid syndrome:: preferential recognition of the major phospholipid-binding site [J].

Arai, T ;

Yoshida, K ;

Kaburaki, J ;

Inoko, H ;

Ikeda, Y ;

Kawakami, Y ;

Kuwana, M .

BLOOD, 2001, 98 (06) :1889-1896

[9] The catastrophic antiphospholipid syndrome, 1998. A review of the clinical features, possible pathogenesis and treatment [J].

Asherson, RA .

LUPUS, 1998, 7 :S55-S62

[10] Antibodies to Domain I of β2Glycoprotein I are in close relation to patients risk categories in Antiphospholipid Syndrome (APS) [J].

Banzato, A. ;

Pozzi, N. ;

Frasson, R. ;

De Filippis, V. ;

Ruffatti, A. ;

Bison, E. ;

Padayattil, S. J. ;

Denas, G. ;

Pengo, V. .

THROMBOSIS RESEARCH, 2011, 128 (06) :583-586

← 1 2 3 4 5 6 7 8 9 10 →