A Lytic Viral Long Noncoding RNA Modulates the Function of a Latent Protein

被引：54

作者：

Campbell, Mel ^{[1
,2
]}

Kim, Kevin Y. ^{[1
,2
]}

Chang, Pei-Ching ^{[4
]}

Huerta, Steve ^{[1
,2
]}

Shevchenko, Bogdan ^{[1
,2
]}

Wang, Don-Hong ^{[1
,2
]}

Izumiya, Chie ^{[1
,2
]}

Kung, Hsing-Jien ^{[2
,3
,5
,6
]}

Izumiya, Yoshihiro ^{[1
,2
,3
]}

机构：

[1] Univ Calif Davis, Dept Dermatol, Davis, CA 95616 USA

[2] Univ Calif Davis, UC Davis Canc Ctr, Davis, CA 95616 USA

[3] Univ Calif Davis, Dept Biochem & Mol Med, Davis, CA 95616 USA

[4] Natl Yang Ming Univ, Inst Microbiol & Immunol, Taipei 112, Taiwan

[5] Natl Hlth Res Inst, Maioli, Taiwan

[6] Taipei Med Univ, Taipei, Taiwan

来源：

JOURNAL OF VIROLOGY | 2014年 / 88卷 / 03期

基金：

美国国家卫生研究院;

关键词：

SARCOMA-ASSOCIATED-HERPESVIRUS; POLYADENYLATED NUCLEAR-RNA; ANTISENSE TRANSCRIPTION; EPISOME PERSISTENCE; GENE-EXPRESSION; KSHV; ANTIGEN; ASSOCIATION; BINDING; GENOME;

D O I：

10.1128/JVI.03251-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Latent Kaposi's sarcoma-associated herpesvirus (KSHV) episomes are coated with viral latency-associated nuclear antigen (LANA). In contrast, LANA rapidly disassociates from episomes during reactivation. Lytic KSHV expresses polyadenylated nuclear RNA (PAN RNA), a long noncoding RNA (lncRNA). We report that PAN RNA promotes LANA-episome disassociation through an interaction with LANA which facilitates LANA sequestration away from KSHV episomes during reactivation. These findings suggest that KSHV may have evolved an RNA aptamer to regulate latent protein function.

引用

页码：1843 / 1848

页数：6

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