Daily oral administration of crocetin attenuates physical fatigue in human subjects

被引：54

作者：

Mizuma, Hiroshi ^{[1
,2
]}

Tanaka, Masaaki ^{[1
,2
,3
]}

Nozaki, Satoshi ^{[1
,2
]}

Mizuno, Kei ^{[1
,2
]}

Tahara, Tsuyoshi ^{[1
,2
]}

Ataka, Suzuka ^{[1
,2
]}

Sugino, Tomohiro ^{[4
]}

Shirai, Tomoko ^{[4
]}

Kajimoto, Yoshitaka ^{[4
]}

Kuratsune, Hirohiko ^{[5
]}

Kajimoto, Osami ^{[4
]}

Watanabe, Yasuyoshi ^{[1
,2
]}

机构：

[1] Osaka City Univ, Grad Sch Med, Dept Physiol, Osaka 5458585, Japan

[2] Japanese Govt, Minist Educ Culture Sports Sci & Technol, 21st Century COE Program Base Overcome Fatigue, Osaka 5458585, Japan

[3] Osaka City Univ, Grad Sch Med, Dept Biomarker & Mol Biophys, Osaka 5458585, Japan

[4] Soiken Inc, Osaka 5600082, Japan

[5] Kansai Univ Welf Sci, Dept Hlth Sci, Fac Hlth Sci Welf, Osaka 5820026, Japan

来源：

NUTRITION RESEARCH | 2009年 / 29卷 / 03期

关键词：

Antioxidant; Ascorbic acid; Bicycle ergometer; Sex difference; Human; VISUAL ANALOG SCALE; ASCORBIC-ACID; MUSCLE; WOMEN;

D O I：

10.1016/j.nutres.2009.02.003

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 [营养与食品卫生学];

摘要：

This study compared the effects of placebo with a carotenoid compound, crocetin, as well as an antioxidant, ascorbic acid, on physical fatigue in humans. In this double-blind, placebo-controlled, 3-way crossover study, 14 Japanese healthy volunteers (7 men and 7 women) were randomized to oral administration of crocetin (15 mg), ascorbic acid (3,000 mg), or placebo for 8 days. Subjects performed workload tests on a bicycle ergometer at fixed workloads for 120 minutes at 2 times (a total of 240 minutes) as a fatigue-inducing physical task. During the physical task, subjects performed nonworkload tests at maximum velocity (MV) of 10 seconds at 30 minutes (30-minute test) after the start of the physical task and at 30 minutes before the end of the task (210-minute test). The change in MV from the 30- to the 210-minute test was significantly higher in men who received crocetin compared with men who received placebo (P < .05). This effect of crocetin was specific to males. Administration of ascorbic acid did not change in MV from the 30-minute to the 210-minute test on males or females. These results suggest that daily administration of crocetin may attenuate physical fatigue in men. (c) 2009 Elsevier Inc. All rights reserved.

引用

页码：145 / 150

页数：6

共 20 条

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Neuroprotection by crocetin in a hemi-parkinsonian rat model [J].