Reproducibility of quantitative 18F-3'-deoxy-3'-fluorothymidine measurements using positron emission tomography

被引:67
作者
de Langen, Adrianus J. [2 ]
Klabbers, Bianca [4 ]
Lubberink, Mark [1 ]
Boellaard, Ronald [1 ]
Spreeuwenberg, Marieke D. [3 ]
Slotman, Ben J. [4 ]
de Bree, Remco [5 ]
Smit, Egbert F. [2 ]
Hoekstra, Otto S. [1 ]
Lammertsma, Adriaan A. [1 ]
机构
[1] Vrije Univ Amsterdam Med Ctr, Dept Nucl Med & PET Res, NL-1007 MB Amsterdam, Netherlands
[2] Vrije Univ Amsterdam Med Ctr, Dept Resp Med, NL-1007 MB Amsterdam, Netherlands
[3] Vrije Univ Amsterdam Med Ctr, Dept Clin Epidemiol & Biostat, NL-1007 MB Amsterdam, Netherlands
[4] Vrije Univ Amsterdam Med Ctr, Dept Radiotherapy, NL-1007 MB Amsterdam, Netherlands
[5] Vrije Univ Amsterdam Med Ctr, Dept Otolaryngol Head & Neck Surg, NL-1007 MB Amsterdam, Netherlands
关键词
Positron emission tomography; Non-small-cell lung cancer; Reproducibility; FLT; CELL LUNG-CANCER; BREAST-CANCER; FDG-PET; KI-67; IMMUNOHISTOCHEMISTRY; ITERATIVE RECONSTRUCTION; IMAGING PROLIFERATION; KINETIC-ANALYSIS; INPUT FUNCTIONS; F-18-FLT PET; IN-VIVO;
D O I
10.1007/s00259-008-0960-5
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Positron emission tomography (PET) using F-18-3'-deoxy-3'-fluorothymidine ([F-18]FLT) allows noninvasive monitoring of tumour proliferation. For serial imaging in individual patients, good reproducibility is essential. The purpose of the present study was to evaluate the reproducibility of quantitative [F-18]FLT measurements. Nine patients with non-small-cell lung cancer (NSCLC) and six with head-and-neck cancer (HNC) underwent [F-18]FLT PET twice within 7 days prior to therapy. The maximum pixel value (SUVmax) and a threshold defined volume (SUV41%) were defined for all delineated lesions. The plasma to tumour transfer constant (K-i) was estimated using both Patlak graphical analysis and nonlinear regression (NLR). NLR was also used to estimate k(3), which, at least in theory, selectively reflects thymidine kinase 1 activity. The level of agreement between test and retest values was assessed using the intraclass correlation coefficient (ICC) and Bland-Altman analysis. All primary tumours and > 90% of clinically suspected locoregional metastases could be delineated. In total, 24 lesions were defined. NLR-derived K-i, Patlak-derived K-i, SUV41% and SUVmax showed excellent reproducibility with ICCs of 0.92, 0.95, 0.98 and 0.93, and SDs of 16%, 12%, 7% and 11%, respectively. Reproducibility was poor for k(3) with an ICC of 0.43 and SD of 38%. Quantitative [F-18]FLT measurements are reproducible in both NSCLC and HNC patients. When monitoring response in individual patients, changes of more than 15% in SUV41%, 20-25% in SUVmax and Patlak-derived K-i, and 32% in NLR3k-derived K-i are likely to represent treatment effects.
引用
收藏
页码:389 / 395
页数:7
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