Dynamical response of nanomechanical oscillators in immiscible viscous fluid for in vitro biomolecular recognition

被引:56
作者
Dorignac, J
Kalinowski, A
Erramilli, S
Mohanty, P
机构
[1] Boston Univ, Dept Phys, Boston, MA 02215 USA
[2] Boston Univ, Coll Engn, Boston, MA 02215 USA
[3] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA
关键词
D O I
10.1103/PhysRevLett.96.186105
中图分类号
O4 [物理学];
学科分类号
0702 ;
摘要
Dynamical response of nanomechanical cantilever structures immersed in a viscous fluid is important to in vitro single-molecule force spectroscopy, biomolecular recognition of disease-specific proteins, and the study of microscopic protein dynamics. Here we study the stochastic response of biofunctionalized nanomechanical cantilever beams in a viscous fluid. Using the fluctuation-dissipation theorem we derive an exact expression for the spectral density of displacement and a linear approximation for resonance frequency shift. We find that in a viscous solution the frequency shift of the nanoscale cantilever is determined by surface stress generated by biomolecular interaction with negligible contributions from mass loading due to the biomolecules.
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页数:4
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