Two-stage individual participant data meta-analysis and generalized forest plots

被引:88
作者
Fisher, David J. [1 ]
机构
[1] UCL, MRC Clin Trials Unit, London, England
关键词
st0384; ipdmetan; forestplot; admetan; ipdover; meta-analysis; forest plot; individual participant data; survival; two-stage; time-to-event; prefix command; subgroup; RANDOM-EFFECTS MODEL; PATIENT DATA; POSTOPERATIVE RADIOTHERAPY; RANDOMIZED-TRIALS; CLINICAL-TRIALS; META-REGRESSION; ONE-STAGE; HETEROGENEITY; TIME;
D O I
10.1177/1536867X1501500203
中图分类号
O1 [数学]; C [社会科学总论];
学科分类号
030301 [社会学]; 070101 [基础数学];
摘要
In this article, I describe a command, ipdmetan, that facilitates two-stage individual participant data meta-analysis of any measure of effect and its standard error by fitting a specified model to data from each study.. The command can estimate random effects and heterogeneity statistics and include additional covariates and interactions. If individual participant data are available for certain studies and aggregate data for others, ipdmetan allows them to be combined in one analysis. This command can produce detailed and flexible forest plots, including ones outside the context of formal meta-analysis.
引用
收藏
页码:369 / 396
页数:28
相关论文
共 38 条
[1]
Biggerstaff BJ, 1997, STAT MED, V16, P753, DOI 10.1002/(SICI)1097-0258(19970415)16:7<753::AID-SIM494>3.0.CO
[2]
2-G
[3]
Individual patient data meta-analysis of time-to-event outcomes: one-stage versus two-stage approaches for estimating the hazard ratio under a random effects model [J].
Bowden, Jack ;
Tierney, Jayne F. ;
Simmonds, Mark ;
Copas, Andrew J. ;
Higgins, Julian P. T. .
RESEARCH SYNTHESIS METHODS, 2011, 2 (03) :150-162
[4]
Postoperative radiotherapy in non-small-cell lung cancer: update of an individual patient data meta-analysis [J].
Burdett, S ;
Stewart, L .
LUNG CANCER, 2005, 47 (01) :81-83
[5]
A closer look at the effects of postoperative radiotherapy by stage and nodal status: Updated results of an individual participant data meta-analysis in non-small-cell lung cancer [J].
Burdett, Sarah ;
Rydzewska, Larysa ;
Tierney, Jayne F. ;
Fisher, David J. .
LUNG CANCER, 2013, 80 (03) :350-352
[6]
Multilevel mixed effects parametric survival models using adaptive Gauss-Hermite quadrature with application to recurrent events and individual participant data meta-analysis [J].
Crowther, Michael J. ;
Look, Maxime P. ;
Riley, Richard D. .
STATISTICS IN MEDICINE, 2014, 33 (22) :3844-3858
[7]
Deeks J.J., 2008, Systematic Reviews in Health Care: Meta-Analysis in Context, Second Edition, P285, DOI DOI 10.1002/9780470693926.CH15
[8]
METAANALYSIS IN CLINICAL-TRIALS [J].
DERSIMONIAN, R ;
LAIRD, N .
CONTROLLED CLINICAL TRIALS, 1986, 7 (03) :177-188
[9]
Random-effects model for meta-analysis of clinical trials: An update [J].
DerSimonian, Rebecca ;
Kacker, Raghu .
CONTEMPORARY CLINICAL TRIALS, 2007, 28 (02) :105-114
[10]
A critical review of methods for the assessment of patient-level interactions in individual participant data meta-analysis of randomized trials, and guidance for practitioners [J].
Fisher, D. J. ;
Copas, A. J. ;
Tierney, J. F. ;
Parmar, M. K. B. .
JOURNAL OF CLINICAL EPIDEMIOLOGY, 2011, 64 (09) :949-967