MUC1 as a target antigen for cancer immunotherapy

被引：85

作者：

Acres, B ^{[1
]}

Limacher, JM ^{[1
]}

机构：

[1] Transgene SA, Dept Med & Regulatory Affairs, F-67082 Strasbourg, France

来源：

EXPERT REVIEW OF VACCINES | 2005年 / 4卷 / 04期

关键词：

cancer immunotherapy; cancer vaccines; clinical immunotherapy; MUC1;

D O I：

10.1586/14760584.4.4.493

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The cancer-associated antigen MUC1 is overexpressed and modified by tumor cells in over half of all cancer cases. Despite various complexities associated with this antigen, it is well worth pursuing as a vaccine for the immunotherapy of cancer. In this review, the authors describe the discovery of MUC1 and its association with cancer, recent observations showing that the immunology of MUC1 is complicated, animal data showing that it can be a target for immune-mediated tumor rejection, and finally, preliminary clinical results to show that vaccine-based immunotherapy with MUC1 does have an impact on the therapy of cancer.

引用

页码：493 / 502

页数：10

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