Coupled plasma filtration adsorption

被引：16

作者：

Bellomo, R ^{[1
]}

Tetta, C ^{[1
]}

Brendolan, A ^{[1
]}

Ronco, C ^{[1
]}

机构：

[1] San Bortolo Hosp, Dept Intens Care, Vicenza, Italy

来源：

BLOOD PURIFICATION | 2002年 / 20卷 / 03期

关键词：

hemofiltration; adsorption; plasma filtration; septic shock; multi-organ failure; critical illness; intensive care; sorbents; resins;

D O I：

10.1159/000047022

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Both pro-inflammatory and anti-inflammatory mediators participate in the pathogenesis of sepsis and explain the failure of specific therapies to improve survival. Continuous extracorporeal therapies have been proposed as a therapeutic option in sepsis. We have studied the effects of plasma filtration associated with adsorption in patients with septic shock. We have shown that such treatment may lead to improved survival in a rabbit model of sepsis and to improved hemodynamics, reduced norepinephrine dose and restoration of near-to-normal responsiveness of blood leukocytes to endotoxin in humans. It is anticipated that treatment of plasma, as a device modular to conventional hemofiltration, may pave the way to innovative approaches to the extracorporeal treatment of septic patients. Copyright (C) 2002 S. Karger AG, Basel.

引用

收藏

页码：289 / 292

页数：4

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