Regulatory Issues for Personalized Pluripotent Cells

被引：42

作者：

Condic, Maureen L. ^{[1
]}

Rao, Mahendra ^{[2
,3
]}

机构：

[1] Univ Utah, Sch Med, Dept Neurobiol & Anat, Salt Lake City, UT 84132 USA

[2] Invitrogen Corp, Regenerat Med, Carlsbad, CA USA

[3] Johns Hopkins Sch Med, Baltimore, MD USA

来源：

STEM CELLS | 2008年 / 26卷 / 11期

关键词：

Induced pluripotent stem cells; Embryonic stem cell; Somatic cell nuclear transfer; Pluripotency; Reprogramming;

D O I：

10.1634/stemcells.2008-0421

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The development of personalized pluripotent stem cells for research and for possible therapies holds out great hope for patients. However, such cells will face significant technical and regulatory challenges before they can be used as therapeutic reagents. Here we consider two possible sources of personalized pluripotent stem cells: embryonic stem cells derived from nuclear transfer (NT-ESCs) and induced pluripotent stem cells (iPSCs) derived from direct reprogramming of adult somatic cells. Both sources of personalized pluripotent stem cells face unique regulatory hurdles that are in some ways significantly higher than those facing stem cells derived from embryos produced by fertilization (ESCs). However, the outstanding long-term potential of iPSCs and their relative freedom from the ethical concerns raised by both ESCs and NT-ESCs makes direct reprogramming an exceptionally promising approach to advancing research and providing therapies in the field of regenerative medicine. STEM CELLS 2008;26:2753-2758

引用

页码：2753 / 2758

页数：6

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