Adipose tissue stem cells: the great WAT hope

被引：103

作者：

Cawthorn, William P. ^{[1
]}

Scheller, Erica L. ^{[1
]}

MacDougald, Ormond A. ^{[1
]}

机构：

[1] Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2012年 / 23卷 / 06期

基金：

美国国家卫生研究院;

关键词：

MESENCHYMAL STROMAL CELLS; DIFFERENTIATION IN-VITRO; BREAST-CANCER CELLS; ACUTE KIDNEY INJURY; BONE-MARROW; MYOCARDIAL-INFARCTION; IMMUNOSUPPRESSIVE PROPERTIES; ERECTILE DYSFUNCTION; PRECURSOR CELLS; PROSTATE TUMOR;

D O I：

10.1016/j.tem.2012.01.003

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The past decade has witnessed an explosion in research into adipose tissue stem cells (ASCs), facilitated by their ease of isolation from white adipose tissue (WAT) and fueled by their therapeutic potential. Recent developments have extended ASC multipotency to include endodermal and ectodermal cell types, as well as the generation of induced pluripotent stem cells. This expanding multipotency has been paralleled by burgeoning translational applications, ranging from tissue engineering to anti-cancer therapy, that are currently subject to clinical trials. However, this promise is tempered by potential pitfalls, such as tumorigenicity, and is further undermined by lingering uncertainties regarding the precise identity of ASCs. Confronting these issues will be essential if we are to bypass the pitfalls and develop the promises of ASCs.

引用

页码：270 / 277

页数：8

共 105 条

[1]

Wound Microenvironment Sequesters Adipose-Derived Stem Cells in a Murine Model of Reconstructive Surgery in the Setting of Concurrent Distant Malignancy [J].

Altman, Andrew M. ;

Prantl, Lukas ;

Muehlberg, Fabian L. ;

Song, Yao-Hua ;

Seidensticker, Max ;

Butler, Charles E. ;

Alt, Eckhard U. .

PLASTIC AND RECONSTRUCTIVE SURGERY, 2011, 127 (04) :1467-1477

[2]

Aoki T, 2010, TISSUE ENG PT A, V16, P2197, DOI [10.1089/ten.tea.2009.0747, 10.1089/ten.TEA.2009.0747]

[3]

Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo [J].

Aurich, H. ;

Sgodda, M. ;

Kaltwasser, P. ;

Vetter, M. ;

Weise, A. ;

Liehr, T. ;

Brulport, M. ;

Hengstler, J. G. ;

Dollinger, M. M. ;

Fleig, W. E. ;

Christ, B. .

GUT, 2009, 58 (04) :570-581

[4]

Adipose tissue-derived mesenchymal stem cells as a source of human hepatocytes [J].

Banas, Agnieszka ;

Teratani, Takumi ;

Yamamoto, Yusuke ;

Tokuhara, Makoto ;

Takeshita, Fumitaka ;

Quinn, Gary ;

Okochi, Hitoshi ;

Ochiya, Takahiro .

HEPATOLOGY, 2007, 46 (01) :219-228

[5]

Rapid hepatic fate specification of adipose-derived stem cells and their therapeutic potential for liver failure [J].

Banas, Agnieszka ;

Teratani, Takumi ;

Yamamoto, Yusuke ;

Tokuhara, Makoto ;

Takeshita, Fumitaka ;

Osaki, Mitsuhiko ;

Kato, Takashi ;

Okochi, Hitoshi ;

Ochiya, Takahiro .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2009, 24 (01) :70-77

[6]

Epithelial differentiation of human adipose tissue-derived adult stem cells [J].

Brzoska, M ;

Geiger, H ;

Gauer, S ;

Baer, P .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 330 (01) :142-150

[7]

Suppression of hepatocyte growth factor production impairs the ability of adipose-derived stem cells to promote ischemic tissue revascularization [J].

Cai, Liying ;

Johnstone, Brian H. ;

Cook, Todd G. ;

Liang, Zhong ;

Traktuev, Dmitry ;

Cornetta, Kenneth ;

Ingram, David A. ;

Rosen, Elliot D. ;

Marcha, Keith L. .

STEM CELLS, 2007, 25 (12) :3234-3243

[8]

IFATS Collection: Human Adipose Tissue-Derived Stem Cells Induce Angiogenesis and Nerve Sprouting Following Myocardial Infarction, in Conjunction with Potent Preservation of Cardiac Function [J].

Cai, Liying ;

Johnstone, Brian H. ;

Cook, Todd G. ;

Tan, Jian ;

Fishbein, Michael C. ;

Chen, Peng-Sheng ;

March, Keith L. .

STEM CELLS, 2009, 27 (01) :230-237

[9]

Casteilla Louis, 2011, World J Stem Cells, V3, P25, DOI 10.4252/wjsc.v3.i4.25

[10]

Adipose tissue stem cells meet preadipocyte commitment: going back to the future [J].

Cawthorn, William P. ;

Scheller, Erica L. ;

MacDougald, Ormond A. .

JOURNAL OF LIPID RESEARCH, 2012, 53 (02) :227-246

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