Muscular dystrophies: alterations in a limited number of cellular pathways?

被引：15

作者：

Toniolo, D

Minetti, C

机构：

[1] CNR, Inst Genet Biochem & Evolut, I-27100 Pavia, Italy

[2] Univ Geneva, Gaslini Inst, I-16147 Genoa, Italy

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1999年 / 9卷 / 03期

关键词：

D O I：

10.1016/S0959-437X(99)80041-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Identification of new genes involved in muscle disorders has dramatically changed the traditional clinical classification of the large and heterogeneous group of the muscular dystrophies. Results obtained in recent years by positional candidate cloning have demonstrated the role of the sarcolemma and of the nuclear envelope in normal muscle function and have elucidated molecular pathways perturbed by mutations that lead to muscular dystrophy.

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收藏

页码：275 / 282

页数：8

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