Determination of the absolute configuration of a key tricyclic component of a novel vasopressin receptor antagonist by use of vibrational circular dichroism

被引：14

作者：

Dyatkin, AB

Freedman, TB

Cao, XL

Dukor, RK

Maryanoff, BE

Maryanoff, CA

Matthews, JM

Shah, RD

Nafie, LA

机构：

[1] RW Johnson Pharmaceut Res Inst, Drug Evaluat, Spring House, PA 19477 USA

[2] RW Johnson Pharmaceut Res Inst, Drug Discovery, Spring House, PA 19477 USA

[3] Syracuse Univ, Dept Chem, Syracuse, NY 13244 USA

[4] BioTools Inc, Lake Zurich, IL USA

来源：

CHIRALITY | 2002年 / 14卷 / 2-3期

关键词：

vibrational circular dichroism; absolute configuration; conformation; benzodiazepine;

D O I：

10.1002/chir.10058

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We present the results of a study using vibrational circular dichroism (VCD) for (+)-1, which furnished an unambiguous determination of its absolute configuration as S. The most abundant conformation of (+)-1 in CDCl3 solution was also established. (C) 2002 Wiley-Liss, Inc.

引用

页码：215 / 219

页数：5

共 21 条

[1] Structure, vibrational absorption and circular dichroism spectra, and absolute configuration of Troger's Base [J].