The intrinsic organization of the central extended amygdala

被引:224
作者
Cassell, MD [1 ]
Freedman, LJ
Shi, CJ
机构
[1] Univ Iowa, Dept Cell Biol & Anat, Iowa City, IA 52242 USA
[2] Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
[3] Emory Univ, Dept Psychiat, Atlanta, GA 30322 USA
来源
ADVANCING FROM THE VENTRAL STRIATUM TO THE EXTENDED AMYGDALA: IMPLICATIONS FOR NEUROPSYCHIATRY AND DRUG ABUSE: IN HONOR OF LENNART HEIMER | 1999年 / 877卷
关键词
D O I
10.1111/j.1749-6632.1999.tb09270.x
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
The central component of the extended amygdala (CEA) comprises the central amygdaloid nucleus (Ce), the dorsal substantia innominata (SI), and the bed nucleus of the stria terminalis (BNST). Anatomical studies have suggested the presence of an intrinsic system of GABAergic neurons that not only connects homologous subareas of the Ce, SI, and BNST but that also acts as an interface between sensory afferents and brain stem-projecting neurons. CEA outputs, with a few exceptions, arise from separate populations of neurons, but all, including GABAergic neurons themselves, are heavily innervated by GABAergic terminals. GABAergic neurons may serve to integrate output activity of the CEA, though GABAergic neurons form a heterogeneous population whose differential intrinsic connections appear related to their peptide content. Afferents from the dysgranular insular cortex and lateral parabrachial complex preferentially innervate GABAergic neurons, suggesting these neurons mag also integrate afferent activity. Afferents from the basolateral amygdala (BL) appear to innervate both output neurons and intrinsic GABAergic neurons. Evidence will be presented to show that BL afferents form synaptic complexes with cortical, GABAergic, and TH-immunoreactive terminal boutons on GABAergic dendritic spines. These complexes may be a key element in control of CEA output activity.
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页码:217 / 241
页数:25
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