Homing phenotypes of tumor-specific CD8 T cells are predetermined at the tumor site by crosspresenting APCs

被引:184
作者
Calzascia, T
Masson, F
Di Berardino-Besson, W
Contassot, E
Wilmotte, R
Aurrand-Lions, M
Rüegg, C
Dietrich, PY
Walker, PR
机构
[1] Univ Hosp Geneva, Div Oncol, Lab Tumour Immunol, CH-1211 Geneva 14, Switzerland
[2] Univ Geneva, Ctr Med, Louis Jeantet Skin Canc Lab, CH-1211 Geneva 4, Switzerland
[3] Univ Geneva, Ctr Med, Dept Pathol & Immunol, CH-1211 Geneva 4, Switzerland
[4] Univ Lausanne, Swiss Inst Expt Canc Res, Lab Ctr Pluridisciplinaire Oncol, CH-1066 Epalinges, Switzerland
关键词
D O I
10.1016/j.immuni.2004.12.008
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Expression of tissue-specific homing molecules directs antigen-experienced T cells to particular peripheral tissues. In studies using soluble antigens that focused on skin and gut, antigen-presenting cells (APCs) within regional lymphoid tissues were proposed to be responsible for imprinting homing phenotypes. Whether this occurs in other sites and after physiologic antigen processing and presentation is unknown. We define in vivo imprinting of distinct homing phenotypes on monospecific T cells responding to antigens expressed by tumors in intracerebral, subcutaneous, and intraperitoneal sites with efficient brain-tropism of CD8 T cells crossprimed in the cervical lymph nodes (LNs). Multiple imprinting programs could occur simultaneously in the same LN when tumors were present in more than one site. Thus, the identity of the LN is not paramount in determining the homing phenotype; this critical functional parameter is dictated upstream at the site of antigen capture by crosspresenting APCs.
引用
收藏
页码:175 / 184
页数:10
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