Polyspecificity of T cell and B cell receptor recognition

被引：157

作者：

Wucherpfennig, Kai W.

Allen, Paul M.

Celada, Franco

Cohen, Irun R.

De Boer, Rob

Garcia, K. Christopher

Goldstein, Byron

Greenspan, Ralph

Hafler, David

Hodgkin, Philip

Huseby, Erik S.

Krakauer, David C.

Nemazee, David

Perelson, Alan S.

Pinilla, Clemencia

Strong, Roland K.

Sercarz, Eli E.

机构：

[1] Dana Farber Canc Inst, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA

[3] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

[4] Univ Genoa, Dept Oncol Biol & Genet, Genoa, Italy

[5] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

[6] Univ Utrecht, Dept Theoret Biol, Utrecht, Netherlands

[7] Stanford Univ, Sch Med, Howard Hughes Med Inst, Dept Microbiol & Immunol, Stanford, CA 94305 USA

[8] Stanford Univ, Sch Med, Howard Hughes Med Inst, Dept Biol Struct, Stanford, CA 94305 USA

[9] Los Alamos Natl Lab, Theoret & Phys Biol Grp, Los Alamos, NM 87545 USA

[10] Inst Neurosci, San Diego, CA 92121 USA

[11] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Neurol, Boston, MA 02115 USA

[12] Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA

[13] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

[14] Natl Jewish Med & Res Ctr, Howard Hughes Med Inst, Denver, CO 80206 USA

[15] Natl Jewish Med & Res Ctr, Dept Integrat Immunol, Denver, CO 80206 USA

[16] Santa Fe Inst, Santa Fe, NM 87501 USA

[17] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

[18] Los Alamos Natl Lab, Dept Theoret Biol & Biophys, Los Alamos, NM 87545 USA

[19] Torrey Pines Inst Mol Studies, Dept Immunochem, San Diego, CA 92121 USA

[20] Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USA

[21] Torrey Pines Inst Mol Studies, Div Immune Regulat, San Diego, CA 92121 USA

来源：

SEMINARS IN IMMUNOLOGY | 2007年 / 19卷 / 04期

关键词：

T cell receptor; peptide; MHC; polyspecificity; recognition;

D O I：

10.1016/j.smim.2007.02.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A recent workshop discussed the recognition of multiple distinct ligands by individual T cell and B cell receptors and the implications of this discovery for lymphocyte biology. The workshop recommends general use of the term polyspecificity because it emphasizes two fundamental aspects, the inherent specificity of receptor recognition and the ability to recognize multiple ligands. Many different examples of polyspecificity and the structural mechanisms were discussed, and the group concluded that polyspecificity is a general, inherent feature of TCR and antibody recognition. This review summarizes the relevance of polyspecificity for lymphocyte development, activation and disease processes. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：216 / 224

页数：9

共 46 条

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