Cymodienol and cymodiene:: new cytotoxic diarylheptanoids from the sea grass Cymodocea nodosa

被引：31

作者：

Kontiza, I

Vagias, C

Jakupovic, J

Moreau, D

Roussakis, C

Roussis, V

机构：

[1] Univ Athens, Sch Pharm, Dept Pharmacognosy & Chem Nat Prod, GR-15771 Athens, Greece

[2] AnalytiCon Discovery GmbH, D-14473 Potsdam, Germany

[3] Fac Pharm, Lab Pharmacogenom Marine, ISOMer, F-44035 Nantes, France

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 16期

关键词：

Cymodocea nodosa; diarylheptanoids; cymodienol; cymodiene;

D O I：

10.1016/j.tetlet.2005.02.123

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The two new diarylheptanoids, cymodienol (1), and cymodiene (2), tobtained from specimens of the sea grass Cymodocea nodosa, collected from the coastal areas of central Greece, are the first members of this class isolated from marine organisms. The chemical structures of the two metabolites were assigned on the basis of their NMR and MS spectroscopic data, including information obtained by 1D- and 2D-NMR experiments. Metabolite 2 possesses an unprecedented skeleton that might be biosynthetically related to metabolite 1. Cymodienol (1) was found to exhibit significant cytotoxic activity against two lung cancer cell lines. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2845 / 2847

页数：3

共 13 条

[1] Growth and primary production of Cymodocea nodosa in a coastal lagoon [J].