Enzymatic lithography of phospholipid bilayer films by stereoselective hydrolysis

被引：18

作者：

Moraille, P

Badia, A

机构：

[1] Univ Montreal, Dept Chem, Montreal, PQ H3C 3J7, Canada

[2] Univ Montreal, Ctr Self Assembled Chem Struct, Montreal, PQ H3C 3J7, Canada

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 18期

关键词：

D O I：

10.1021/ja0511669

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The stereoselective phospholipase A2-catalyzed hydrolysis of patterned phospholipid bilayers consisting of the l- and d-isomers of α-dilauroylphosphatidylcholine (DLPC) and α-dipalmitoylphosphatidylcholine (DPPC) is reported. The stereochemically directed enzyme lithography demonstrated herein allows the parallel modification of large surface areas and constitutes a potentially useful method to structure biomimetic films, given the stereospecific action of many enzymes. Copyright © 2005 American Chemical Society.

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页码：6546 / 6547

页数：2

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