Nitric oxide synthase 2 and cyclooxygenase 2 interactions in inflammation

被引:96
作者
Weinberg, JB
机构
[1] Duke Univ, Durham, NC 27705 USA
[2] VA Med Ctr, Durham, NC 27705 USA
关键词
nitric oxide; prostaglandin; monocyte; macrophage; inflammation; rheumatoid arthritis;
D O I
10.1385/IR:22:2-3:319
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Nitric oxide (NO) and prostaglandin (PG) E-2 produced by NO synthase type 2 (NOS2) and cyclooxygenase type 2 (COX2), respectively, are important mediators in inflammation. There is much information regarding their roles in models of inflammation in mice and in humans with diseases such as rheumatoid arthritis (RA). A variety of stimuli including cytokines, microbial components, immune complexes, and mechanical stress can induce both NOS2 and COX2 mRNA transcription and protein synthesis and enhance inflammation. This has been demonstrated in both mice and humans. NOS2-specific inhibitors reduce inflammation in mice, and COX2-specific inhibitors reduce inflammation in mice and in humans. There is significant cross-talk between PGE(2)/NO and COX2/NOS2. Treatments that inhibit both NOS2 and COX2 should provide the most potent antiinflammatory effects.
引用
收藏
页码:319 / 341
页数:23
相关论文
共 179 条
[1]   Pathogenesis of influenza virus-induced pneumonia: Involvement of both nitric oxide and oxygen radicals [J].
Akaike, T ;
Noguchi, Y ;
Ijiri, S ;
Setoguchi, K ;
Suga, M ;
Zheng, YM ;
Dietzschold, B ;
Maeda, H .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (06) :2448-2453
[2]   SUPPRESSION OF LYMPHOCYTE-PROLIFERATION THROUGH THE NITRIC-OXIDE SYNTHESIZING PATHWAY [J].
ALBINA, JE ;
HENRY, WL .
JOURNAL OF SURGICAL RESEARCH, 1991, 50 (04) :403-409
[3]  
ALVAROGRACIA JM, 1991, J IMMUNOL, V146, P3365
[4]   THE MODE OF ACTION OF ASPIRIN-LIKE DRUGS - EFFECT ON INDUCIBLE NITRIC-OXIDE SYNTHASE [J].
AMIN, AR ;
VYAS, P ;
ATTUR, M ;
LESZCZYNSKAPIZIAK, J ;
PATEL, IR ;
WEISSMANN, G ;
ABRAMSON, SB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (17) :7926-7930
[5]   Nitric oxide, malaria, and anemia: Inverse relationship between nitric oxide production and hemoglobin concentration in asymptomatic, malaria-exposed children [J].
Anstey, NM ;
Granger, DL ;
Hassanali, MY ;
Mwaikambo, ED ;
Duffy, PE ;
Weinberg, JB .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1999, 61 (02) :249-252
[6]   Effects of age and parasitemia on nitric oxide production/leukocyte nitric oxide synthase type 2 expression in asymptomatic, malaria-exposed children [J].
Anstey, NM ;
Weinberg, JB ;
Wang, ZQ ;
Mwaikambo, ED ;
Duffy, PE ;
Granger, DL .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1999, 61 (02) :253-258
[7]   Nitric oxide in Tanzanian children with malaria: Inverse relationship between malaria severity and nitric oxide production nitric oxide synthase type 2 expression [J].
Anstey, NM ;
Weinberg, JB ;
Hassanali, M ;
Mwaikambo, ED ;
Manyenga, D ;
Misukonis, MA ;
Arnelle, DR ;
Hollis, D ;
McDonald, MI ;
Granger, DL .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (02) :557-567
[8]  
Appleton I, 1996, Adv Pharmacol, V35, P27, DOI 10.1016/S1054-3589(08)60274-4
[9]   ACID LABILE ALPHA-INTERFERON IN SERA AND SYNOVIAL-FLUIDS FROM PATIENTS WITH JUVENILE ARTHRITIS [J].
ARVIN, AM ;
MILLER, JJ .
ARTHRITIS AND RHEUMATISM, 1984, 27 (05) :582-585
[10]   FEEDBACK INHIBITION OF NITRIC-OXIDE SYNTHASE ACTIVITY BY NITRIC-OXIDE [J].
ASSREUY, J ;
CUNHA, FQ ;
LIEW, FY ;
MONCADA, S .
BRITISH JOURNAL OF PHARMACOLOGY, 1993, 108 (03) :833-837