Mechanism of proliferation arrest of embryonic cells of Xenopus by diterpene compounds

被引：15

作者：

Okouchi, T

Abe, T

Araki, S

Arai, S

Iida, T

Wang, LY

Kitanaka, S

Miyata, S

机构：

[1] Nihon Univ, Coll Humanities & Sci, Dept Chem, Biochem Lab,Setagaya Ku, Tokyo 1568550, Japan

[2] Shenyang Pharmaceut Univ, Dept Nat Prod Chem, Shenyang 110016, Peoples R China

[3] Nihon Univ, Coll Pharm, Funabashi, Chiba 2748555, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 11期

关键词：

diterpenes; proliferation arrest; inhibition of entrance into S phase; inhibition of chromatin condensation;

D O I：

10.1016/j.bmc.2005.02.064

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Three diterpene compounds isolated from the anti-cancer herbal medicine kansui, namely, kansuinin B, 20-OD-ingenol Z, and 20-OD-ingenol E, specifically inhibited the proliferation of isolated embryonic cells from Xenopus embryos. We conducted a cytologic study to determine the mechanism underlying the arrest of the cellular proliferation by these compounds. While kansuinin B and 20-OD-ingenol Z treatment decreased the cell numbers in the S phase and the M phase substages of the cell cycle, 20-OD-ingenol E inhibited mitosis. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：3847 / 3851

页数：5

共 21 条

[1]

CHROMOSOME ASSEMBLY INVITRO - TOPOISOMERASE-II IS REQUIRED FOR CONDENSATION [J].