Induction of cyclooxygenase-2 mRNA in gerbil hippocampal neurons after transient forebrain ischemia

被引：66

作者：

Ohtsuki, T

Kitagawa, K

Yamagata, K

Mandai, K

Mabuchi, T

Matsushita, K

Yanagihara, T

Matsumoto, M

机构：

[1] OSAKA UNIV, SCH MED, DEPT MED 1, SUITA, OSAKA 565, JAPAN

[2] OSAKA UNIV, SCH MED, DEPT PHARMACOL, OSAKA, JAPAN

[3] OSAKA UNIV, SCH MED, DEPT NEUROL, OSAKA, JAPAN

来源：

BRAIN RESEARCH | 1996年 / 736卷 / 1-2期

关键词：

cyclooxygenase-2; cerebral ischemia; hippocampus;

D O I：

10.1016/0006-8993(96)00948-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the effect of brain ischemia on neuronal expression of cyclooxygenase-2 gene in the hippocampus. Transient forebrain ischemia was produced by occluding bilateral carotid arteries for 5 min in Mongolian gerbil. Northern blotting and in situ hybridization demonstrated that expression of cyclooxygenase-2 mRNA was transiently induced in the hippocampal neurons. Although future studies will be needed to clarify if induced cyclooxygenase-2 following ischemia is involved in neuronal damage or neuronal protection, selective cyclooxygenase-2 inhibitors may be a new therapeutical approach for the treatment of stroke.

引用

页码：353 / 356

页数：4

共 24 条

[1]

Adams J, 1996, J NEUROCHEM, V66, P6

[2]

BROOKS PM, 1991, NEW ENGL J MED, V324, P1716

[3] INDUCTION BY LIPOPOLYSACCHARIDE OF CYCLOOXYGENASE-2 MESSENGER-RNA IN FAT BRAIN - ITS POSSIBLE ROLE IN THE FEBRILE RESPONSE [J].