Protection against cutaneous leishmaniasis induced by recombinant antigens in murine and nonhuman primate models of the human disease

被引:124
作者
Campos-Neto, A
Porrozzi, R
Greeson, K
Coler, RN
Webb, JR
Seiky, YAW
Reed, SG
Grimaldi, G
机构
[1] Infect Dis Res Inst, Seattle, WA 98104 USA
[2] Corixa Corp, Seattle, WA 98104 USA
[3] Med Sch Itajuba, Itajuba, MG, Brazil
[4] Inst Oswaldo Cruz, BR-20001 Rio De Janeiro, Brazil
[5] Univ Ottawa, Fac Med, Ottawa, ON, Canada
关键词
D O I
10.1128/IAI.69.6.4103-4108.2001
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Leishmaniasis affects approximately 2 million people each year throughout the world. This high incidence is due in part to the lack of an efficacious vaccine. We present evidence that the recombinant leishmanial antigens LmSTI1 and TSA, which we identified and characterized previously, induce excellent protection in both murine and nonhuman primate (rhesus monkey) models of human cutaneous leishmaniasis. The remarkable protection induced by LmSTI1 and TSA in an animal model that is evolutionarily close to humans qualifies this antigen combination as a promising candidate subunit vaccine against human leishmaniasis.
引用
收藏
页码:4103 / 4108
页数:6
相关论文
共 29 条
  • [1] Subunit vaccination of mice against new world cutaneous leishmaniasis: Comparison of three proteins expressed in amastigotes and six adjuvants
    Aebischer, T
    Wolfram, M
    Patzer, SI
    Ilg, T
    Wiese, M
    Overath, P
    [J]. INFECTION AND IMMUNITY, 2000, 68 (03) : 1328 - 1336
  • [2] THE ADJUVANT EFFECT OF INTERLEUKIN-12 IN A VACCINE AGAINST LEISHMANIA-MAJOR
    AFONSO, LCC
    SCHARTON, TM
    VIEIRA, LQ
    WYSOCKA, M
    TRINCHIERI, G
    SCOTT, P
    [J]. SCIENCE, 1994, 263 (5144) : 235 - 237
  • [3] Leishmania amazonensis: The Asian rhesus macaques (Macaca mulatta) as an experimental model for study of cutaneous leishmaniasis
    Amaral, VF
    Ransatto, VAO
    ConceicaoSilva, F
    Molinaro, E
    Ferreira, V
    Coutinho, SG
    McMahonPratt, D
    Grimaldi, G
    [J]. EXPERIMENTAL PARASITOLOGY, 1996, 82 (01) : 34 - 44
  • [4] Cell populations in lesions of cutaneous leishmaniasis of Leishmania (L.) amazonensis-infected rhesus macaques, Macaca mulatta
    Amaral, VF
    Pirmez, C
    Gonçalves, AJS
    Ferreira, V
    Grimaldi, G
    [J]. MEMORIAS DO INSTITUTO OSWALDO CRUZ, 2000, 95 (02): : 209 - 216
  • [5] Field trial of a vaccine against new world cutaneous leishmaniasis in an at-risk child population: Safety, immunogenicity, and efficacy during the first 12 months of follow-up
    Armijos, RX
    Weigel, MM
    Aviles, H
    Maldonado, R
    Racines, J
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1998, 177 (05) : 1352 - 1357
  • [6] Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection
    Baba, TW
    Liska, V
    Hofmann-Lehmann, R
    Vlasak, J
    Xu, WD
    Ayehunie, S
    Cavacini, LA
    Posner, MR
    Katinger, H
    Stiegler, G
    Bernacky, BJ
    Rizvi, TA
    Schmidt, R
    Hill, LR
    Keeling, ME
    Lu, YC
    Wright, JE
    Chou, TC
    Ruprecht, RM
    [J]. NATURE MEDICINE, 2000, 6 (02) : 200 - 206
  • [7] Cloning, characterization and serological evaluation of K9 and K26:: two related hydrophilic antigens of Leishmania chagasi
    Bhatia, A
    Daifalla, NS
    Jen, SY
    Badaro, R
    Reed, SG
    Skeiky, YAW
    [J]. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1999, 102 (02) : 249 - 261
  • [8] EFFECTS OF IL-12 ON IMMUNE-RESPONSES TO MICROBIAL INFECTIONS - A KEY MEDIATOR IN REGULATING DISEASE OUTCOME
    BIRON, CA
    GAZZINELLI, RT
    [J]. CURRENT OPINION IN IMMUNOLOGY, 1995, 7 (04) : 485 - 496
  • [9] CLONING AND EXPRESSION OF A LEISHMANIA-DONOVANI GENE INSTRUCTED BY A PEPTIDE ISOLATED FROM MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II MOLECULES OF INFECTED MACROPHAGES
    CAMPOSNETO, A
    SOONG, L
    CORDOVA, JL
    SANTANGELO, D
    SKEIKY, YAW
    RUDDLE, NH
    REED, SG
    JANEWAY, C
    MCMAHONPRATT, D
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (05) : 1423 - 1433
  • [10] Vaccine for prophylaxis and immunotherapy Brazil
    Genaro, O
    deToledo, VPCP
    DaCosta, CA
    Hermeto, MV
    Afonso, LCC
    Mayrink, W
    [J]. CLINICS IN DERMATOLOGY, 1996, 14 (05) : 503 - 512