Macroporous biphasic calcium phosphate ceramics versus injectable bone substitute:: a comparative study 3 and 8 weeks after implantation in rabbit bone

被引:73
作者
Gauthier, O
Goyenvalle, E
Bouler, JM
Guicheux, J
Pilet, P
Weiss, P
Daculsi, G
机构
[1] Ecole Natl Vet Nantes, Lab Chirurg, F-44307 Nantes 03, France
[2] Fac Chirurg Dent, INSERM 99 03, Lab Rech Mat Interet Biol, F-44042 Nantes 1, France
关键词
D O I
10.1023/A:1011284517429
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Macroporous biphasic calcium phosphate ceramics (MBCP) and a calcium phosphate injectable bone substitute (IBS), obtained by the association of biphasic calcium phosphate (BCP) ceramic granules and an aqueous solution of a cellulosic polymer, were compared in the same animal model. The two tested biomaterials were implanted in distal femoral osseous defects in rabbits. Qualitative and quantitative histological evaluation was performed three and eight weeks after implantation to investigate bone colonization and ceramic biodegradation associated with the two bone substitutes. Both biomaterials expressed osteoconduction properties and supported the apposition of a well-mineralized lamellar newly-formed bone. Bone colonization occurred much earlier and faster for IBS than for MBCP implants, although the respective rates of newly-formed bone after eight weeks of implantation did not differ significantly. For both biomaterials, ceramic resorption occurred regularly throughout the implantation period, though to a greater extent with IBS than with MBCP implants. The associated polymer in IBS produced intergranular spaces allowing body fluids to reach each BCP ceramic granule immediately after implantation, which may have favored osteoblastic activity, new bone formation and ceramic resorption. This completely interconnected open macroporosity could account for the earlier and more satisfactory bone substitution achieved with IBS. (C) 2001 Kluwer Academic Publishers.
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页码:385 / 390
页数:6
相关论文
共 41 条
[1]  
BARBIE C, 1990, Clinical Materials, V5, P251, DOI 10.1016/0267-6605(90)90023-O
[2]   TRANSFORMATION OF BIPHASIC CALCIUM-PHOSPHATE CERAMICS INVIVO - ULTRASTRUCTURAL AND PHYSICOCHEMICAL CHARACTERIZATION [J].
DACULSI, G ;
LEGEROS, RZ ;
NERY, E ;
LYNCH, K ;
KEREBEL, B .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1989, 23 (08) :883-894
[3]   Biphasic calcium phosphate concept applied to artificial bone, implant coating and injectable bone substitute [J].
Daculsi, G .
BIOMATERIALS, 1998, 19 (16) :1473-1478
[4]   MACROPOROUS CALCIUM-PHOSPHATE CERAMIC FOR LONG-BONE SURGERY IN HUMANS AND DOGS - CLINICAL AND HISTOLOGICAL STUDY [J].
DACULSI, G ;
PASSUTI, N ;
MARTIN, S ;
DEUDON, C ;
LEGEROS, RZ ;
RAHER, S .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1990, 24 (03) :379-396
[5]   Microcharacterization of a new injectable polymer/ceramic composite as bone substitute in spine surgery [J].
Dupraz, A ;
Nguyen, TP ;
Richard, M ;
Delecrin, J ;
Daculsi, G .
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 1996, 7 (01) :52-55
[6]  
Dupraz A, 1998, J BIOMED MATER RES, V42, P368, DOI 10.1002/(SICI)1097-4636(19981205)42:3<368::AID-JBM4>3.3.CO
[7]  
2-V
[8]   Influence of a cellulosic ether carrier on the structure of biphasic calcium phosphate ceramic particles in an injectable composite material [J].
Dupraz, A ;
Nguyen, TP ;
Richard, M ;
Daculsi, G ;
Passuti, N .
BIOMATERIALS, 1999, 20 (07) :663-673
[9]   Biomechanical and histological evaluation of a calcium phosphate cement [J].
Frankenburg, EP ;
Goldstein, SA ;
Bauer, TW ;
Harris, SA ;
Poser, RD .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1998, 80A (08) :1112-1124
[10]  
Gauthier O, 1999, J BIOMED MATER RES, V47, P28, DOI 10.1002/(SICI)1097-4636(199910)47:1<28::AID-JBM4>3.0.CO