Glia in pathological pain: A role for fractalkine

被引：85

作者：

Milligan, E. D. ^{[1
]}

Sloane, E. M. ^{[2
,3
]}

Watkins, L. R. ^{[2
,3
]}

机构：

[1] Univ New Mexico, Hlth Sci Ctr, Dept Neurosci, Albuquerque, NM 87131 USA

[2] Univ Colorado, Dept Psychol, Boulder, CO 80309 USA

[3] Univ Colorado, Ctr Neurosci, Boulder, CO 80309 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2008年 / 198卷 / 1-2期

关键词：

neuropathic pain; spinal cord; microglia; astrocytes; interleukin-10; gene therapy;

D O I：

10.1016/j.jneuroim.2008.04.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Microglia and/or astrocytes play a significant role in the creation and maintenance of exaggerated pain states with inflammatory and/or neuropathic etiologies. The chemokine, fractalkine, has several functions, including the newly recognized role of mediating neuropathic pain conditions. Although constitutively expressed and released during inflammation, increased release of fractalkine binds to and activates microglia leading to pathological pain. We review the critical role of fractalkine in neuron-to-glial communication after peripheral nerve injury and inflammation and explore anti-inflammatory cytokines like interleukin-10 as a novel and effective approach for clinical pain control. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：113 / 120

页数：8

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