Neurodegenerative diseases: Quantitative predictions of protein-RNA interactions

被引：57

作者：

Cirillo, Davide ^{[1
,2
]}

Agostini, Federico ^{[1
,2
]}

Klus, Petr ^{[1
,2
]}

Marchese, Domenica ^{[1
,2
]}

Rodriguez, Silvia ^{[1
,2
]}

Bolognesi, Benedetta ^{[1
,2
]}

Gaetano Tartaglia, Gian ^{[1
,2
]}

机构：

[1] CRG, Barcelona 08003, Spain

[2] UPF, Barcelona 08003, Spain

来源：

RNA | 2013年 / 19卷 / 02期

关键词：

protein-RNA interactions; noncoding RNA; neurodegeneration; autogenous regulation; RNA aptamers; AMYLOID PRECURSOR PROTEIN; IRON-RESPONSIVE ELEMENT; AMYOTROPHIC-LATERAL-SCLEROSIS; FMR1; MESSENGER-RNA; FRAGILE-X-SYNDROME; BINDING PROTEIN; AGGREGATION-PRONE; PRION-PROTEIN; REGULATORY PROTEIN-1; ALZHEIMER-DISEASE;

D O I：

10.1261/rna.034777.112

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Increasing evidence indicates that RNA plays an active role in a number of neurodegenerative diseases. We recently introduced a theoretical framework, catRAPID, to predict the binding ability of protein and RNA molecules. Here, we use catRAPID to investigate ribonucleoprotein interactions linked to inherited intellectual disability, amyotrophic lateral sclerosis, Creutzfeuld-Jakob, Alzheimer's, and Parkinson's diseases. We specifically focus on (1) RNA interactions with fragile X mental retardation protein FMRP; (2) protein sequestration caused by CGG repeats; (3) noncoding transcripts regulated by TAR DNA-binding protein 43 TDP-43; (4) autogenous regulation of TDP-43 and FMRP; (5) iron-mediated expression of amyloid precursor protein APP and alpha-synuclein; (6) interactions between prions and RNA aptamers. Our results are in striking agreement with experimental evidence and provide new insights in processes associated with neuronal function and misfunction.

引用

页码：129 / 140

页数：12

共 57 条

[1] X-inactivation: quantitative predictions of protein interactions in the Xist network [J].