Age-related muscle dysfunction

被引：154

作者：

Thompson, LaDora V. ^{[1
]}

机构：

[1] Univ Minnesota, Dept Phys Med & Rehabil, Minneapolis, MN 55455 USA

来源：

EXPERIMENTAL GERONTOLOGY | 2009年 / 44卷 / 1-2期

关键词：

Actin; Myosin; Aged muscle; Enzymatic activity; oxidative modifications; TANDEM MASS-SPECTROMETRY; RAT SKELETAL-MUSCLE; MYOSIN ATPASE ACTIVITY; GLYCATION END-PRODUCT; IN-VIVO; PROTEOMIC IDENTIFICATION; PROTEIN NITRATION; DEPENDENT ACCUMULATION; CONTRACTILE PROPERTIES; FORCE GENERATION;

D O I：

10.1016/j.exger.2008.05.003

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Aging is associated with a progressive decline of muscle mass, strength, and quality, a condition described as sarcopenia. Despite the significance of skeletal muscle atrophy, the mechanisms responsible for the deterioration of muscle performance are only partially understood. The purpose of this review is to highlight cellular, molecular, and biochemical changes that contribute to age-related muscle dysfunction. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：106 / 111

页数：6

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