Induced regeneration-the progress and promise of direct reprogramming for heart repair

被引：66

作者：

Addis, Russell C.

Epstein, Jonathan A. ^{[1
]}

机构：

[1] Univ Penn, Dept Cell & Dev Biol, Perelman Sch Med, Inst Regenerat Med, Philadelphia, PA 19104 USA

来源：

NATURE MEDICINE | 2013年 / 19卷 / 07期

基金：

美国国家卫生研究院;

关键词：

PLURIPOTENT STEM-CELLS; IN-VIVO; MOUSE FIBROBLASTS; DIRECT CONVERSION; ISCHEMIC CARDIOMYOPATHY; DOPAMINERGIC-NEURONS; CARDIAC FIBROBLASTS; MASTER REGULATOR; CARDIOMYOCYTES; TISSUE;

D O I：

10.1038/nm.3225

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Regeneration of cardiac tissue has the potential to transform cardiovascular medicine. Recent advances in stem cell biology and direct reprogramming, or transdifferentiation, have produced powerful new tools to advance this goal. In this Review we examine key developments in the generation of new cardiomyocytes in vitro as well as the exciting progress that has been made toward in vivo reprogramming of cardiac tissue. We also address controversies and hurdles that challenge the field.

引用

收藏

页码：829 / 836

页数：8

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