Proteomics in postgenomic neuroscience: the end of the beginning

被引：93

作者：

Choudhary, J ^{[1
]}

Grant, SGN ^{[1
]}

机构：

[1] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England

来源：

NATURE NEUROSCIENCE | 2004年 / 7卷 / 05期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nn1240

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Proteomics is complementary to genomic approaches anchored in DNA and RNA. Global characterization of proteins is providing new insights into general biological structures as well as synapses, receptor complexes and other neuronal and glial features. Current challenges for proteomics of the nervous system include problems relating to sample preparation, brain complexity, limited databases and informatics tools. The combination of proteomics with other global functional genomic approaches at the levels of genome and transcriptome, together with network biology, will provide important bridges between genes, physiology and pathology.

引用

页码：440 / 445

页数：6

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