The Role of Small GTPases in Neuronal Morphogenesis and Polarity

被引：84

作者：

Gonzalez-Billault, Christian ^{[1
,2
]}

Munoz-Llancao, Pablo ^{[1
,2
]}

Henriquez, Daniel R. ^{[1
,2
]}

Wojnacki, Jose ^{[3
]}

Conde, Cecilia ^{[3
]}

Caceres, Alfredo ^{[3
]}

机构：

[1] Univ Chile, Fac Sci, Dept Biol, Lab Cell & Neuronal Dynam, Santiago, Chile

[2] Univ Chile, ICDB, Santiago, Chile

[3] INIMEC CONICET, Neurobiol Lab, Inst Mercedes & Martin Ferreyra, Cordoba, Argentina

来源：

CYTOSKELETON | 2012年 / 69卷 / 07期

关键词：

neuronal polarity; cytoskeleton dynamics; Rac1; Cdc42; RhoA; TC10; GUANINE-NUCLEOTIDE EXCHANGE; RHO-FAMILY GTPASES; GTP-BINDING PROTEINS; DENDRITIC SPINE DEVELOPMENT; GDP-DISSOCIATION INHIBITOR; PLECKSTRIN HOMOLOGY DOMAIN; LINKED MENTAL-RETARDATION; GROWTH CONE; ACTIVATING PROTEIN; NEURITE OUTGROWTH;

D O I：

10.1002/cm.21034

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The highly dynamic remodeling and cross talk of the microtubule and actin cytoskeleton support neuronal morphogenesis. Small RhoGTPases family members have emerged as crucial regulators of cytoskeletal dynamics. In this review we will comprehensively analyze findings that support the participation of RhoA, Rac, Cdc42, and TC10 in different neuronal morphogenetic events ranging from migration to synaptic plasticity. We will specifically address the contribution of these GTPases to support neuronal polarity and axonal elongation. (C) 2012 Wiley Periodicals, Inc

引用

页码：464 / 485

页数：22

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