Size series of small indium arsenide-zinc selenide core-shell nanocrystals and their application to in vivo imaging

被引:342
作者
Zimmer, JP
Kim, SW
Ohnishi, S
Tanaka, E
Frangioni, JV
Bawendi, MG
机构
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
[2] Beth Israel Deaconess Med Ctr, Div Hematol Oncol, Boston, MA 02215 USA
[3] Beth Israel Deaconess Med Ctr, Dept Radiol, Boston, MA 02215 USA
[4] Ajou Univ, Dept Mol Sci & Technol, Suwon 443749, South Korea
关键词
D O I
10.1021/ja0579816
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
We have developed a size series of unusually small, water-soluble (InAs)ZnSe (core)shell quantum dots (QDs) that emit in the near-infrared and exhibit new behavior in vivo, including multiple sequential lymph node mapping and extravasation from the vasculature. The biological utility of these fluorescent probes resulted from our intentional choice to match the semiconductor material and water-soluble ligand with a desired final hydrodynamic diameter and emission wavelength. Copyright © 2006 American Chemical Society.
引用
收藏
页码:2526 / 2527
页数:2
相关论文
共 21 条
[1]   Formation of high quality InP and InAs nanocrystals in a noncoordinating solvent [J].
Battaglia, D ;
Peng, XG .
NANO LETTERS, 2002, 2 (09) :1027-1030
[2]  
Cao YW, 1999, ANGEW CHEM INT EDIT, V38, P3692, DOI 10.1002/(SICI)1521-3773(19991216)38:24<3692::AID-ANIE3692>3.0.CO
[3]  
2-W
[4]   Growth and properties of semiconductor core/shell nanocrystals with InAs cores [J].
Cao, YW ;
Banin, U .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (40) :9692-9702
[5]   In vivo cancer targeting and imaging with semiconductor quantum dots [J].
Gao, XH ;
Cui, YY ;
Levenson, RM ;
Chung, LWK ;
Nie, SM .
NATURE BIOTECHNOLOGY, 2004, 22 (08) :969-976
[6]   On the synthesis and manipulation of InAs quantum dots [J].
Green, M ;
Norager, S ;
Moriarty, P ;
Motevalli, M ;
O'Brien, P .
JOURNAL OF MATERIALS CHEMISTRY, 2000, 10 (08) :1939-1943
[7]   Conjugation chemistry and bioapplications of semiconductor box nanocrystals prepared via dendrimer bridging [J].
Guo, WZ ;
Li, JJ ;
Wang, YA ;
Peng, XG .
CHEMISTRY OF MATERIALS, 2003, 15 (16) :3125-3133
[8]   Colloidal chemical synthesis and characterization of InAs nanocrystal quantum dots [J].
Guzelian, AA ;
Banin, U ;
Kadavanich, AV ;
Peng, X ;
Alivisatos, AP .
APPLIED PHYSICS LETTERS, 1996, 69 (10) :1432-1434
[9]   Chaperonin-mediated stabilization and ATP-triggered release of semiconductor nanoparticles [J].
Ishii, D ;
Kinbara, K ;
Ishida, Y ;
Ishii, N ;
Okochi, M ;
Yohda, M ;
Aida, T .
NATURE, 2003, 423 (6940) :628-632
[10]   Long-term multiple color imaging of live cells using quantum dot bioconjugates [J].
Jaiswal, JK ;
Mattoussi, H ;
Mauro, JM ;
Simon, SM .
NATURE BIOTECHNOLOGY, 2003, 21 (01) :47-51