The spiroketals containing a benzyloxymethyl moiety at C8 position showed the most potent apoptosis-inducing activity.

被引：49

作者：

Mitsuhashi, S

Shima, H

Kawamura, T

Kikuchi, K

Oikawa, M

Ichihara, A

Oikawa, H

机构：

[1] Hokkaido Univ, Inst Immunol Sci, Biochem Sect, Kita Ku, Sapporo, Hokkaido 0600815, Japan

[2] Hokkaido Univ, Fac Agr, Dept Biosci & Chem, Kita Ku, Sapporo, Hokkaido 0608589, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(99)00309-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The spiroketals containing a benzyloxymethyl moiety at the C8 position showed the most potent apoptosis-inducing activity, whereas its analogous compounds lacking any substituent at C8 or possessing ones other than the benzyloxymethyl moiety at C8 were all much less active, These results strongly suggest an important role of the benzyloxymethyl moiety linked to the C8 oxygen atom. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2007 / 2012

页数：6

共 8 条

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