In vivo cholinergic circuit evaluation in frontotemporal and Alzheimer dementias

被引：98

作者：

Di Lazzaro, V

Pilato, F

Dileone, M

Saturno, E

Oliviero, A

Marra, C

Daniele, A

Ranieri, F

Gainotti, G

Tonali, PA

机构：

[1] Univ Cattolica Sacro Cuore, Ist Neurol, I-00168 Rome, Italy

[2] Hosp Nacl Paraplej, Unidad Neurol Func, Toledo, Spain

[3] Fdn Don C Gnocchi, Rome, Italy

来源：

NEUROLOGY | 2006年 / 66卷 / 07期

关键词：

D O I：

10.1212/01.wnl.0000204183.26231.23

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The test of short latency afferent inhibition (SAI) of the motor cortex is helpful in demonstrating dysfunction of central cholinergic circuits in Alzheimer disease (AD). The authors evaluated SAI in 20 patients with frontotemporal dementia (FTD) and compared data with those from 20 patients with AD and 20 controls. SAI was normal in FTD, whereas it was reduced in AD. SAI may represent an additional tool to discriminate FTD from AD.

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页码：1111 / 1113

页数：3

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