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The mechanisms of Hedgehog signalling and its roles in development and disease

被引：1516
作者：
Briscoe, James [1 ]
Therond, Pascal P. [2 ,3 ]
机构：
[1] Natl Inst Med Res, MRC, London NW7 1AA, England
[2] CNRS, UMR 7277, INSERM, UMR 1091,IBV, F-75700 Paris, France
[3] Univ Nice Sophia Antipolis, Ctr Biochim, F-06108 Nice 2, France
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2013年 / 14卷 / 07期
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
CHOLESTEROL-MODIFIED HEDGEHOG; HEPARAN-SULFATE INTERACTIONS; DROSOPHILA PATCHED GENE; STEROL-SENSING DOMAIN; GLI-BINDING-AFFINITY; HUMAN SONIC HEDGEHOG; LONG-RANGE ACTIVITY; PROTEIN-KINASE-A; PRIMARY CILIUM; DALLY-LIKE;
D O I：
10.1038/nrm3598
中图分类号：
Q2 [细胞生物学];
学科分类号：
071013 [干细胞生物学];
摘要：
The cloning of the founding member of the Hedgehog (HH) family of secreted proteins two decades ago inaugurated a field that has diversified to encompass embryonic development, stem cell biology and tissue homeostasis. Interest in HH signalling increased when the pathway was implicated in several cancers and congenital syndromes. The mechanism of HH signalling is complex and remains incompletely understood. Nevertheless, studies have revealed novel biological insights into this system, including the function of HH lipidation in the secretion and transport of this ligand and details of the signal transduction pathway, which involves Patched 1, Smoothened and GLI proteins (Cubitus interruptus in Drosophila melanogaster), as well as, in vertebrates, primary cilia.
引用
收藏
页码：416 / 429
页数：14
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