Bone marrow transplantation for chronic granulomatous disease: long-term follow-up and review of literature

被引：33

作者：

Leung, TF ^{[1
]}

Chik, KW ^{[1
]}

Li, CK ^{[1
]}

Shing, MMK ^{[1
]}

Yuen, PMP ^{[1
]}

机构：

[1] Chinese Univ Hong Kong, Lady Pao Childrens Canc Ctr, Dept Paediat, Prince Wales Hosp,Div Haematol & Oncol, Hong Kong, Peoples R China

来源：

BONE MARROW TRANSPLANTATION | 1999年 / 24卷 / 05期

关键词：

bone marrow transplantation; chronic granulomatous disease;

D O I：

10.1038/sj.bmt.1701932

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Chronic granulomatous disease (CGD) is a heterogeneous group of disorders,vith defective respiratory burst activity in phagocytes which results in recurrent pyogenic infections. We report an 8-year-old boy with X-linked CGD who received an HLA-identical BRIT from his sister. The nitroblue tetrazolium test returned to normal 3 months post transplant. Neutrophil engraftment has been stable for 7 Sears post BRIT. Our patient was the eighth case of CGD successfully treated by BRIT, Conditioning regimens in these patients have consisted mainly of BU and CY. We suggest that BRIT is a safe and effective method of cure for patients with CGD, BRIT should be considered for patients with HLA-identical siblings.

引用

页码：567 / 570

页数：4

共 25 条

[1] Donor lymphocyte infusion at unstable mixed chimerism in an allogeneic BMT recipient for chronic granulomatous disease [J].