HIV T cell vaccines, the importance of clades

被引：34

作者：

McMichael, A ^{[1
]}

Mwau, M ^{[1
]}

Hanke, T ^{[1
]}

机构：

[1] John Radcliffe Hosp, MRC, Human Immunol Unit, Weatherall Inst Mol Med, Oxford OX3 9DS, England

来源：

VACCINE | 2002年 / 20卷 / 15期

关键词：

HIV vaccines; CD8 T cells; HIV clades;

D O I：

10.1016/S0264-410X(02)00067-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Development of an HIV vaccine presents a formidable challenge. One of the unresolved. yet central issues is the importance of HIV variability. Here we argue that even with the recent focus on the induction of T cell-mediated immunity, HIV vaccines should match the local circulating HIV clades. Whether used alone or in a combination with vaccines eliciting HIV-neutralizing antibodies, efforts must be made to develop a T cell vaccine that stimulates a broad and long-lasting response. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：1918 / 1921

页数：4

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