Protective effects of quercetin supplementation against short-term toxicity of cadmium-induced hematological impairment, hypothyroidism, and testicular disturbances in albino rats

被引：35

作者：

Badr, Gehan M. ^{[1
,2
]}

Elsawy, Hany ^{[3
,4
]}

Sedky, Azza ^{[1
,5
]}

Eid, Rania ^{[6
]}

Ali, Awatef ^{[5
]}

Abdallah, Basem M. ^{[1
,7
,8
]}

Alzahrani, Abdullah M. ^{[1
]}

Abdel-Moneim, Ashraf M. ^{[1
,5
]}

机构：

[1] King Faisal Univ, Coll Sci, Fac Sci, Dept Biol Sci, Al Hufuf 31982, Al Ahsa, Saudi Arabia

[2] Ain Shams Univ, Fac Sci, Dept Zool, Cairo, Egypt

[3] King Faisal Univ, Fac Sci, Dept Chem, Al Hufuf, Al Ahsa, Saudi Arabia

[4] Tanta Univ, Fac Sci, Dept Chem, Tanta, Egypt

[5] Alexandria Univ, Fac Sci, Dept Zool, Alexandria, Egypt

[6] Aswan Univ, Fac Med, Dept Physiol, Aswan, Egypt

[7] Odense Univ Hosp, Dept Endocrinol, Endocrine Res KMEB, Odense, Denmark

[8] Univ Southern Denmark, Odense, Denmark

来源：

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH | 2019年 / 26卷 / 08期

关键词：

Cadmium chloride; Quercetin; Hematological markers; Thyroid hormones; Reproductive dysfunction; INDUCED OXIDATIVE STRESS; DIETARY ANTIOXIDANT; THYROID-DYSFUNCTION; LEYDIG-CELLS; DAMAGE; LEAD; EXPOSURE; BLOOD; ANEMIA; NEPHROTOXICITY;

D O I：

10.1007/s11356-019-04276-1

中图分类号：

X [环境科学、安全科学];

学科分类号：

083001 [环境科学];

摘要：

The aim of this study was to evaluate the probable protective effect of quercetin (QUE) against cadmium (Cd)-induced sub-chronic toxicity in rats. Adult male rats were given either Cd (as cadmium chloride; 5mg/kg) alone or in combination with QUE (50mg/kg) daily for 4weeks by oral gavage. At the end of the experimental period, Cd accumulation, and selected hematological, thyroid, and reproductive markers were assessed. Results revealed that Cd treatment significantly increased Cd concentrations in blood, thyroid gland, and testicular tissue of rats. Cd also caused a decline in hemoglobin content, hematocrit value, and total erythrocyte and leucocyte counts. Further, significant suppressions in the blood levels of hormones related to thyroid gland function, and male reproductive hormones (i.e., testosterone, luteinizing hormone and follicle-stimulating hormone), were observed in Cd-treated rats compared to the control. In parallel, low sperm count and sperm motility, increased sperm abnormalities, and marked pathology occurred in testis. Combination with QUE recorded amelioration of the deleterious effects of Cd, involving regulation of hematological toxicity and thyroid hormonal levels and subsequently modulation of testicular function. In conclusion, it appears that dietary QUE can rescue from Cd-induced hematological dysfunctions and testicular damage by reversing the hypothyroid state.

引用

页码：8202 / 8211

页数：10

共 71 条

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Dietary Antioxidant, Quercetin, Protects Sertoli-Germ Cell Coculture from Atrazine-Induced Oxidative Damage [J].