Chitosans for gene delivery

被引：445

作者：

Borchard, G ^{[1
]}

机构：

[1] Leiden Amsterdam Ctr Drug Res, Div Pharmaceut Technol, NL-2300 RA Leiden, Netherlands

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2001年 / 52卷 / 02期

关键词：

chitosan; non-viral gene delivery; transfection;

D O I：

10.1016/S0169-409X(01)00198-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Efficient non-viral gene delivery based on cationic polymers as DNA-condensing agents is dependent on a variety of factors, e.g. complex size, complex stability, toxicity, immunogenicity, protection against DNase degradation, and intracellular trafficking and processing of the DNA. This review examines the advances in the application of chitosan and chitosan derivatives to non-viral gene delivery, and gives an overview of transfection studies which have been performed recently using chitosans as transfection agents. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：145 / 150

页数：6

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