Treatment for acute stroke-the end of the citicoline saga

被引:14
作者
Clark, Wayne M. [1 ]
Clark, Tegan D. [1 ]
机构
[1] Oregon Hlth & Sci Univ, Oregon Stroke Ctr UHS 44, Dept Neurol, Portland, OR 97201 USA
关键词
ACUTE ISCHEMIC-STROKE; TRIAL;
D O I
10.1038/nrneurol.2012.166
中图分类号
R74 [神经病学与精神病学];
学科分类号
100204 [神经病学];
摘要
Over the past two decades, trials of citicoline for treatment of acute stroke have produced conflicting results. A recent large clinical trial of citicoline in acute stroke suggests a lack of efficacy of this therapy, seemingly signalling the end to the citicoline saga.
引用
收藏
页码:484 / 485
页数:2
相关论文
共 11 条
[1]
[Anonymous], J GERONTOL B
[2]
Aronowski J, 1996, NEUROL RES, V18, P570
[3]
A randomized efficacy trial of citicoline in patients with acute ischemic stroke [J].
Clark, WM ;
Williams, BJ ;
Selzer, KA ;
Zweifler, RM ;
Sabounjian, LA ;
Gammans, RE .
STROKE, 1999, 30 (12) :2592-2597
[4]
A randomized dose-response trial of citicoline in acute ischemic stroke patients [J].
Clark, WM ;
Warach, SJ ;
Pettigrew, LC ;
Gammans, RE ;
Sabounjian, LA .
NEUROLOGY, 1997, 49 (03) :671-678
[5]
A phase III randomized efficacy trial of 2000 mg citicoline in acute ischemic stroke patients [J].
Clark, WM ;
Wechsler, LR ;
Sabounjian, LA ;
Schwiderski, UE .
NEUROLOGY, 2001, 57 (09) :1595-1602
[6]
Oral citicoline in acute ischemic stroke -: An individual patient data pooling analysis of clinical trials [J].
Dávalos, A ;
Castillo, J ;
Alvarez-Sabín, J ;
Secades, JJ ;
Mercadal, J ;
López, S ;
Cobo, E ;
Warach, S ;
Sherman, D ;
Clark, WM ;
Lozano, R .
STROKE, 2002, 33 (12) :2850-2857
[7]
LIPOSOMES AS IN-VIVO CARRIERS FOR CITICOLINE - EFFECTS ON RAT CEREBRAL POSTISCHEMIC REPERFUSION [J].
FRESTA, M ;
PUGLISI, G ;
DIGIACOMO, C ;
RUSSO, A .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1994, 46 (12) :974-981
[8]
Qureshi N, 1996, NEW ENGL J MED, V334, P1406
[9]
TREATMENT OF ACUTE CEREBRAL INFARCTION WITH A CHOLINE PRECURSOR IN A MULTICENTER DOUBLE-BLIND PLACEBO-CONTROLLED STUDY [J].
TAZAKI, Y ;
SAKAI, F ;
OTOMO, E ;
KUTSUZAWA, T ;
KAMEYAMA, M ;
OMAE, T ;
FUJISHIMA, M ;
SAKUMA, A .
STROKE, 1988, 19 (02) :211-216
[10]
Warach S, 2000, ANN NEUROL, V48, P713, DOI 10.1002/1531-8249(200011)48:5<713::AID-ANA4>3.0.CO