Salt consumption-dependent association of the GNB3 gene polymorphism with type 2 DM

被引：24

作者：

Daimon, Makoto ^{[1
,2
]}

Sato, Hidenori ^{[1
,3
]}

Sasaki, Satoshi ^{[4
]}

Toriyama, Sayumi ^{[1
,3
]}

Emi, Mitsuru ^{[1
,3
]}

Muramatsu, Masaaki ^{[3
,5
]}

Hunt, Steven C. ^{[6
]}

Hopkins, Paul N. ^{[6
]}

Karasawa, Shigeru ^{[1
]}

Wada, Kiriko ^{[1
]}

Jimbu, Yumi ^{[1
]}

Kameda, Wataru ^{[1
]}

Susa, Shinji ^{[1
]}

Oizumi, Toshihide ^{[1
]}

Fukao, Akira ^{[2
]}

Kubota, Isao ^{[2
]}

Kawata, Sumio ^{[2
]}

Kato, Takeo ^{[1
,2
]}

机构：

[1] Yamagata Univ, Sch Med, DNHMED, Yamagata 9909585, Japan

[2] Yamagata Univ, Sch Med, 21st Century Ctr Excellence Program Study Grp, Yamagata 99023, Japan

[3] HuBit Genomix Res Inst, Tokyo, Japan

[4] Univ Tokyo, Dept Social & Prevent Epidemiol, Sch Publ Hlth, Tokyo, Japan

[5] Tokyo Med & Dent Univ, Med Res Inst, Dept Mol Epidemiol, Tokyo, Japan

[6] Univ Utah, Sch Med, Dept Internal Med, Cardiovasc Genet Div, Salt Lake City, UT 84112 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 374卷 / 03期

关键词：

gene environment relationship; population-based study; Takahata study; G-protein beta 3 subunit; salt consumption; sodium-proton exchanger; genetic variation; SNP; hypertension; type; 2; diabetes;

D O I：

10.1016/j.bbrc.2008.07.065

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The associations of the C825T polymorphism (rs5443) of the G-protein beta 3 subunit (GNB3) gene and eight adjacent single nucleotide polymorphisms (SNPs) with diabetes were examined using a Japanese population (n (M/W): 2956 (1335/1621): age: 63.0 +/- 10.2 years). Fasting plasma glucose (FPG) levels were significantly associated with the C825T polymorphism and two flanking SNPs (rs2301339 and rs5446) (p = 0.002, 0.001, and 0.008, respectively). A case-control association Study of the C825T polymorphism with diabetes using multiple logistic regression analysis showed a significant association of the genotypes TT + TC with an odds ratio of 0.62 (p = 0.008) independent of age, gender, and BMI. The effects of salt consumption on the association were then examined (n = 1635). The FPG levels were significantly associated with the C825T polymorphism only in subjects with low salt consumption (<12.44 g/day) (p = 0.002). A case-control association study also showed a significant association with diabetes only in subjects with low salt consumption (p = 0.006). (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：576 / 580

页数：5

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