Toll-like receptors: key players in antiviral immunity

被引：109

作者：

Arpaia, Nicholas ^{[1
]}

Barton, Gregory M. ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Div Immunol & Pathogenesis, Berkeley, CA 94720 USA

来源：

CURRENT OPINION IN VIROLOGY | 2011年 / 1卷 / 06期

关键词：

RESPIRATORY SYNCYTIAL VIRUS; HERPES-SIMPLEX-VIRUS; NF-KAPPA-B; PLASMACYTOID DENDRITIC CELLS; PATTERN-RECOGNITION RECEPTORS; CYTOMEGALOVIRUS-INFECTION; CUTTING EDGE; IN-VIVO; NONSTRUCTURAL PROTEINS; INTERFERON INDUCTION;

D O I：

10.1016/j.coviro.2011.10.006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

TLRs are a family of innate receptors whose specificities are predetermined in the germline. Therefore, TLRs have evolved to recognize conserved features of microbes. Viruses typically lack the conserved features common to other pathogen classes, so the innate immune system has evolved to recognize viral nucleic acid as a hallmark of viral infection. In this review we discuss examples of TLR-mediated viral recognition and the functional consequences of this recognition for antiviral immunity.

引用

收藏

页码：447 / 454

页数：8

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