Translational biomarkers of acetaminophen-induced acute liver injury

被引：61

作者：

Beger, Richard D. ^{[1
]}

Bhattacharyya, Sudeepa ^{[2
,3
]}

Yang, Xi ^{[1
]}

Gill, Pritmohinder S. ^{[2
,3
]}

Schnackenberg, Laura K. ^{[1
]}

Sun, Jinchun ^{[1
]}

James, Laura P. ^{[2
,3
]}

机构：

[1] US FDA, Natl Ctr Toxicol Res, Div Syst Biol, Jefferson, AR 72079 USA

[2] Univ Arkansas Med Sci, Dept Pediat, Little Rock, AR 72205 USA

[3] Arkansas Childrens Hosp, Clin Pharmacol & Toxicol Sect, Little Rock, AR 72202 USA

来源：

ARCHIVES OF TOXICOLOGY | 2015年 / 89卷 / 09期

关键词：

Acetaminophen; MicroRNA; Proteomics; Metabolomics; Biomarkers; GAP METABOLIC-ACIDOSIS; SERUM BILE-ACIDS; PERFORMANCE LIQUID-CHROMATOGRAPHY; GROUP BOX-1 PROTEIN; ANION GAP; INDUCED HEPATOTOXICITY; MASS SPECTROMETRY; CIRCULATING MICRORNAS; SAFETY BIOMARKERS; 3-(CYSTEIN-S-YL)ACETAMINOPHEN ADDUCTS;

D O I：

10.1007/s00204-015-1519-4

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 [卫生毒理学];

摘要：

Acetaminophen (APAP) is a commonly used analgesic drug that can cause liver injury, liver necrosis and liver failure. APAP-induced liver injury is associated with glutathione depletion, the formation of APAP protein adducts, the generation of reactive oxygen and nitrogen species and mitochondrial injury. The systems biology omics technologies (transcriptomics, proteomics and metabolomics) have been used to discover potential translational biomarkers of liver injury. The following review provides a summary of the systems biology discovery process, analytical validation of biomarkers and translation of omics biomarkers from the nonclinical to clinical setting in APAP-induced liver injury.

引用

页码：1497 / 1522

页数：26

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