Reactions at solid-liquid interfaces. The mechanism and kinetics of the fluorination of 2,4-dinitrochlorobenzene using solid potassium fluoride in dimethylformamide

被引:14
作者
Macfie, G [1 ]
Brookes, BA [1 ]
Compton, RG [1 ]
机构
[1] Univ Oxford, Phys & Theoret Chem Lab, Oxford OX1 3QZ, England
关键词
D O I
10.1021/jp012612r
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
The halogen exchange reaction of 2,4-dichloronitrobenzene with potassium fluoride in dimethylformamide containing tetrabutylammonium salts has been studied employing an electrochemical detection methodology based upon the use of square wave voltammetry to follow the loss of reactant and the formation of the product and intermediates. The results obtained show that the kinetics of loss of parent material behave on one hand as a dissolution-rate-controlled process and on the other as a homogeneous chemical process, Initially homogeneous reaction dominates the observed kinetics as the presaturated solution is stripped of fluoride ion; at longer time, the observed kinetics are controlled by the rate of KF dissolution, Modeling the system using a fully implicit finite difference method with Richtmyer modification (FIRM algorithm) yielded a mean value for the homogeneous rate constant for the formation of 2,4-dinitrofluorobenzene by reaction of 2,4-dichloronitrobenzene with fluoride ion in DMF at 85 degreesC of 640 +/- 250 mol(-1) cm(3) s(-1) and a mean value for the saturation concentration of fluoride ion of (6.5 +/- 0.5) x 10(-6) mol cm(-3), Ultrasound was found not to significantly enhance the rate of the reaction in the intensity range studied. Furthermore, the utility of microelectrodes for obtaining simple quantifiable voltammetric responses from Compounds of which the macroelectrode responses are complicated by chemical followup steps is demonstrated, Ultrasonically induced mixing has been shown to facilitate reproducible microelectrode responses in intrinsically heterogeneous systems.
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收藏
页码:12534 / 12546
页数:13
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