Preventing abnormalities in signal transduction of T cells in cancer: The promise of cytokine gene therapy

被引：78

作者：

Zier, K ^{[1
]}

Gansbacher, B ^{[1
]}

Salvadori, S ^{[1
]}

机构：

[1] MEM SLOAN KETTERING CANC CTR,DEPT MED,DIV HEMATOL ONCOL,NEW YORK,NY 10021

来源：

IMMUNOLOGY TODAY | 1996年 / 17卷 / 01期

关键词：

D O I：

10.1016/0167-5699(96)80567-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent evidence suggests that T cells from tumor-bearing patients exhibit abnormalities in signal transduction that render them unresponsive to appropriate activation signals. Here, Karen Zier, Bernd Gansbacher and Silvia Salvadori review evidence that gene therapy with interleukin I (IL-2)-secreting tumor-cell vaccines may prevent such signaling defects.

引用

页码：39 / 45

页数：7

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