On-water chemistry:: Copper-catalyzed straightforward synthesis of benzo[b]furan derivatives in neat water

被引：145

作者：

Carril, M ^{[1
]}

SanMartin, R ^{[1
]}

Tellitu, I ^{[1
]}

Domínguez, E ^{[1
]}

机构：

[1] Euskal Herriko Unibertsitatea, Kimika Organikoa Saila 2, Zientzia Eta Teknol Fak, Bilbao 48080, Spain

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 07期

关键词：

D O I：

10.1021/ol060274c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A more sustainable protocol leading to 2-alkyl- or 2-aryl-substituted benzo[b]furans is reported, involving a copper-TMEDA complex which catalyzes the transformation of readily available ketone derivatives into the corresponding benzofurans in good to excellent yields. The reaction is accomplished using water as the solvent without organic cosolvents, and one example of catalyst reutilization is also presented.

引用

页码：1467 / 1470

页数：4

共 21 条

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